 | GALANIN: BASIC RESEARCH DISCOVERIES AND THERAPEUTIC IMPLICATIONS
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 863:94-107 (1998)
© 1998 New York Academy of Sciences
Molecular Biology and Pharmacology of Galanin Receptors
THERESA BRANCHEKa,
KELLI E. SMITH AND
MARY W. WALKER
Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey 07652, USA
aCorresponding author. Phone, 201-261-1331 ext 118; fax, 201-261-0623; e-mail, tabranchek{at}synapticcorp.com
Galanin was first isolated 15 years ago. Diversity of galanin receptors has been suspected from the study of native tissues and functional responses to galanin and galanin-like peptides in vitro and in vivo. The recent application of molecular biologic techniques to clone galanin receptors has extended this diversity. So far, three galanin receptor subtypes, GALR1, GALR2, and GALR3, have been cloned from both human and rat. Their molecular structure, pharmacologic profiles, tissue distribution, and signal transduction properties have been partially elucidated.
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