 | VIP, PACAP, AND RELATED PEPTIDES: THIRD INTERNATIONAL SYMPOSIUM
Copyright © 1998 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 865:290-296 (1998)
© 1998 New York Academy of Sciences
VIP and Breast Cancer
T. W. MOODYa,d,
J. LEYTONa,
I. GOZESb,
L. LANG AND
W. C. ECKELMANc
aMedicIne Branch, National Cancer Institute, Rockville, Maryland, USA
bDepartment of Pathological Chemistry, University of Tel Aviv, Tel Aviv, Israel
cPositron Emission Tomography Department, ClInical Center, Bethesda, Maryland, USA
dCorrespondIng author: Dr. Terry W. Moody, MedicIne Branch, Bldg. KWC, Rm. 300, 9610 Medical Center Drive, Rockville, MD 20850 USA; Tel.: 301-402-3128; Fax: 301-402-4422
VIP 1 receptors are present In breast cancer cells. VIP elevates the cAMP and stimulates nuclear oncogene expression In MCF-7 cells. VIPhybrid is a VIP receptor antagonist that Inhibits breast cancer proliferation. A VIP analog has been developed for imagIng breast tumors. Therefore VIP 1 receptors may be utilized for the early detection and treatment of breast cancer.
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