 | HEMATOPOIETIC STEM CELLS BIOLOGY AND TRANSPLANTATION
Copyright © 1999 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 872:289-304 (1999)
© 1999 New York Academy of Sciences
Stem Cells, Pre-Progenitor Cells and Lineage-Committed Cells: Are Our Dogmas Correct?
D. METCALFa
The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, 3050 Victoria, Australia
aPhone, +61 3-9345-2555; fax, +61 3-9347-0852.
Recent developments warrant careful reexamination of several of the central dogmas of hematopoiesis. The bioassays previously used may have predetermined which subsets of hematopoietic stem cells are regarded as having long-term repopulating activity and thus have produced misleading data. Lineage commitment in multipotential cells has been regarded as an immutable stochastic process but may be a process that can be modified by extrinsic signaling. Finally, loss of self-renewal activity has been regarded as progressive and irreversible but this response to signaling can be blocked by cytokine-inducible modulating proteins.
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