 | ADVANCING FROM THE VENTRAL STRIATUM TO THE EXTENDED AMYGDALA: IMPLICATIONS FOR NEUROPSYCHIATRY AND DRUG ABUSE
Copyright © 1999 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 877:64-70 (1999)
© 1999 New York Academy of Sciences
Involvement of the Pallidal-thalamocortical Circuit in Adaptive Behavior
PETER W. KALIVASa,c,
LYNN CHURCHILLb AND
ANASTASIA ROMANIDESa
aDepartment of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA
bDepartment of VCAPP, Washington State University, Pullman, Washington, USA
cSend correspondence to Peter Kalivas, Ph.D., Department of Physiology and Neuroscience, Medical University of South Carolina, 167 Ashley Avenue, Suite 607, P.O. Box 25077, Charleston, South Carolina 29425. Voice: 843-792-4424; fax: 843-792-4423; kalivasp{at}musc.edu
Interconnections among the ventral mesencephalon, nucleus accumbens, and ventral pallidum are critical in the initiation of adaptive behavioral responses to environmental stimuli. Within this circuit are two highly topographically organized subcircuits that are differentially interconnected with limbic and motor circuitry in the brain. However, there is not a great deal of anatomical interconnection between the limbic and motor subcircuits. A polysynaptic connection between the two subcircuits involves projections from the limbic ventral pallidum to the mediodorsal thalamus to the prefrontal cortex back to the motor regions of the nucleus accumbens. In the present report we show that this connection is critical in the expression of motor behavior elicited by opioids and the capacity of a rat to perform in a task requiring spatial working memory.
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