 | CELL AND MOLECULAR BIOLOGY OF PANCREATIC CARCINOMA: RECENT DEVELOPMENTS IN RESEARCH AND EXPERIMENTAL THERAPY
Copyright © 1999 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 880:94-102 (1999)
© 1999 New York Academy of Sciences
Sp1 and Its Likes: Biochemical and Functional Predictions for a Growing Family of Zinc Finger Transcription Factors
TIFFANY COOKa,
BRIAN GEBELEINb AND
RAUL URRUTIAa,b,c,d
aGastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
bDepartment of Molecular Neurosciences, Mayo Clinic, Rochester, Minnesota 55905, USA
cDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
dAddress for correspondence: Dr. Raul Urrutia, Gastroenterology Research Unit, 2-445A Alfred Building, 200 First Street SW, Rochester, MN 55905. Phone, 507/255-6028; fax, 507/255-6318; e-mail, urrutia.raul{at}mayo.edu
The discovery and functional characterization of Sp1 as a GC-rich binding zinc finger protein provided a useful paradigm for understanding mechanisms mediating transcriptional activation in eukaryotic cells. This early paradigm suggested that promoters carrying GC-rich sequences are activated by Sp1 through its interaction with proteins from the basal transcriptional machinery to upregulate gene expression. Since the time of this seminal work, studies from several laboratories have led to the discovery of many Sp1-like transcription factors containing highly homologous DNA binding motifs that bind to similar sequences. Consequently, this knowledge poses many important questions regarding whether these related proteins have similar or antagonistic biochemical and functional properties to Sp1. The goal of this article is to use available database information and recent experimental evidence to describe the current repertoire of Sp1-like zinc finger transcription factors in mammalian cells. Furthermore, we discuss structural and functional studies that reveal that these proteins may share a role in morphogenetic pathways. Altogether, this information is aimed at better understanding how this growing family of transcription factors work to regulate gene expression and morphogenesis.
This article has been cited by other articles:
|
|
|
|
 
R. Kekuda, P. Saha, and U. Sundaram
Role of Sp1 and HNF1 transcription factors in SGLT1 regulation during chronic intestinal inflammation
Am J Physiol Gastrointest Liver Physiol,
June 1, 2008;
294(6):
G1354 - G1361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Taheri and H. E. P. Bazan
Platelet-Activating Factor Overturns the Transcriptional Repressor Disposition of Sp1 in the Expression of MMP-9 in Human Corneal Epithelial Cells
Invest. Ophthalmol. Vis. Sci.,
May 1, 2007;
48(5):
1931 - 1941.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Buck, M. Buchholz, M. Wagner, G. Adler, T. Gress, and V. Ellenrieder
The Tumor Suppressor KLF11 Mediates a Novel Mechanism in Transforming Growth Factor {beta}-Induced Growth Inhibition That Is Inactivated in Pancreatic Cancer
Mol. Cancer Res.,
November 1, 2006;
4(11):
861 - 872.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. O. Boylan, L. I. Jepeal, and M. M. Wolfe
Sp1/Sp3 binding is associated with cell-specific expression of the glucose-dependent insulinotropic polypeptide receptor gene
Am J Physiol Endocrinol Metab,
June 1, 2006;
290(6):
E1287 - E1295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Sarek, A. Jarviluoma, and P. M. Ojala
KSHV viral cyclin inactivates p27KIP1 through Ser10 and Thr187 phosphorylation in proliferating primary effusion lymphomas
Blood,
January 15, 2006;
107(2):
725 - 732.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Wu, H.-P. Kim, H.-H. Xue, H. Liu, K. Zhao, and W. J. Leonard
Interleukin-21 Receptor Gene Induction in Human T Cells Is Mediated by T-Cell Receptor-Induced Sp1 Activity
Mol. Cell. Biol.,
November 15, 2005;
25(22):
9741 - 9752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Zhan, D. Yu, J. Liu, J. Hannay, and R. E. Pollock
Transcriptional Repression of Protein Kinase C{alpha} via Sp1 by Wild Type p53 Is Involved in Inhibition of Multidrug Resistance 1 P-Glycoprotein Phosphorylation
J. Biol. Chem.,
February 11, 2005;
280(6):
4825 - 4833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bellanne-Chantelot, S. Clauin, T. Leblanc, B. Cassinat, F. Rodrigues-Lima, S. Beaufils, C. Vaury, M. Barkaoui, O. Fenneteau, M. Maier-Redelsperger, et al.
Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register
Blood,
June 1, 2004;
103(11):
4119 - 4125.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Livengood and J. K. Nyborg
The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression
Nucleic Acids Res.,
May 20, 2004;
32(9):
2829 - 2837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Curtin, H. A. Ferris, M. Hakli, M. Gibson, O. A. Janne, J. J. Palvimo, and M. A. Shupnik
Small Nuclear RING Finger Protein Stimulates the Rat Luteinizing Hormone-{beta} Promoter by Interacting with Sp1 and Steroidogenic Factor-1 and Protects from Androgen Suppression
Mol. Endocrinol.,
May 1, 2004;
18(5):
1263 - 1276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. J. Daniels and G. K. Andrews
Dynamics of the metal-dependent transcription factor complex in vivo at the mouse metallothionein-I promoter
Nucleic Acids Res.,
December 1, 2003;
31(23):
6710 - 6721.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Wei, W. K. Miskimins, and R. Miskimins
The Sp1 Family of Transcription Factors Is Involved in p27Kip1-Mediated Activation of Myelin Basic Protein Gene Expression
Mol. Cell. Biol.,
June 15, 2003;
23(12):
4035 - 4045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gaudreault, P. Carrier, K. Larouche, S. Leclerc, M. Giasson, L. Germain, and S. L. Guerin
Influence of Sp1/Sp3 Expression on Corneal Epithelial Cells Proliferation and Differentiation Properties in Reconstructed Tissues
Invest. Ophthalmol. Vis. Sci.,
April 1, 2003;
44(4):
1447 - 1457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Aerts, G. Thijs, B. Coessens, M. Staes, Y. Moreau, and B. D. Moor
Toucan: deciphering the cis-regulatory logic of coregulated genes
Nucleic Acids Res.,
March 15, 2003;
31(6):
1753 - 1764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. French, C. S. Malone, R. R. Shen, M. Renard, S. E. Henson, M. D. Miner, R. Wall, and M. A. Teitell
Sp1 Transactivation of the TCL1 Oncogene
J. Biol. Chem.,
January 3, 2003;
278(2):
948 - 955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. P. Scherrer, D. A. Rice, and L. L. Heckert
Expression of Steroidogenic Factor 1 in the Testis Requires an Interactive Array of Elements Within Its Proximal Promoter
Biol Reprod,
November 1, 2002;
67(5):
1509 - 1521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Ye and S. F. Liu
Lipopolysaccharide Down-regulates Sp1 Binding Activity by Promoting Sp1 Protein Dephosphorylation and Degradation
J. Biol. Chem.,
August 23, 2002;
277(35):
31863 - 31870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Lacroix, C. Lipcey, J. Imbert, and B. Kahn-Perles
Sp1 Transcriptional Activity Is Up-regulated by Phosphatase 2A in Dividing T Lymphocytes
J. Biol. Chem.,
March 8, 2002;
277(11):
9598 - 9605.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-H. Li, A. L. Cheng, H. Zhou, S. Lam, M. Rao, H. Li, and X.-J. Li
Interaction of Huntington Disease Protein with Transcriptional Activator Sp1
Mol. Cell. Biol.,
March 1, 2002;
22(5):
1277 - 1287.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Lei and L. L. Heckert
Sp1 and Egr1 Regulate Transcription of the Dmrt1 Gene in Sertoli Cells
Biol Reprod,
March 1, 2002;
66(3):
675 - 684.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Nishi, M. Senoo, K. H. Nishi, B. Murphy, T. Rikiyama, Y. Matsumura, S. Habu, and A. C. Johnson
p53 Homologue p63 Represses Epidermal Growth Factor Receptor Expression
J. Biol. Chem.,
November 2, 2001;
276(45):
41717 - 41724.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Tsavachidou, W. Podrzucki, J. Seykora, and S. L. Berger
Gene Array Analysis Reveals Changes in Peripheral Nervous System Gene Expression following Stimuli That Result in Reactivation of Latent Herpes Simplex Virus Type 1: Induction of Transcription Factor Bcl-3
J. Virol.,
October 15, 2001;
75(20):
9909 - 9917.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-S. Zhang, M. C. Moncrieffe, J. Kaczynski, V. Ellenrieder, F. G. Prendergast, and R. Urrutia
A Conserved {alpha}-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A
Mol. Cell. Biol.,
August 1, 2001;
21(15):
5041 - 5049.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kim, S. You, J. Farris, L. K. Foster, Y.-J. Choi, and D. N. Foster
Gonad-Specific Expression of Two Novel Chicken Complementary DNA Isoforms
Biol Reprod,
May 1, 2001;
64(5):
1473 - 1480.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Gebelein and R. Urrutia
Sequence-Specific Transcriptional Repression by KS1, a Multiple-Zinc-Finger-Kruppel-Associated Box Protein
Mol. Cell. Biol.,
February 1, 2001;
21(3):
928 - 939.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. Zhang, D. Yu, M. Hu, S. Xiong, A. Lang, L. M. Ellis, and R. E. Pollock
Wild-Type p53 Suppresses Angiogenesis in Human Leiomyosarcoma and Synovial Sarcoma by Transcriptional Suppression of Vascular Endothelial Growth Factor Expression
Cancer Res.,
July 1, 2000;
60(13):
3655 - 3661.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Cook and R. Urrutia
TIEG proteins join the Smads as TGF-beta -regulated transcription factors that control pancreatic cell growth
Am J Physiol Gastrointest Liver Physiol,
April 1, 2000;
278(4):
G513 - G521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. H. Raskind, K. K. Niakan, J. Wolff, M. Matsushita, T. Vaughan, G. Stamatoyannopoulos, C. Watanabe, J. Rios, and H. D. Ochs
Mapping of a syndrome of X-linked thrombocytopenia with thalassemia to band Xp11-12: further evidence of genetic heterogeneity of X-linked thrombocytopenia
Blood,
April 1, 2000;
95(7):
2262 - 2268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Cook, B. Gebelein, M. Belal, K. Mesa, and R. Urrutia
Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger Proteins
J. Biol. Chem.,
October 8, 1999;
274(41):
29500 - 29504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-L. Zheng, S. Matsubara, C. Diao, M. D. Hollenberg, and N. C. W. Wong
Activation of Apolipoprotein AI Gene Expression by Protein Kinase A and Kinase C through Transcription Factor, Sp1
J. Biol. Chem.,
October 6, 2000;
275(41):
31747 - 31754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. West, Y. Ito, Y. Birger, Y. Postnikov, H. Shirakawa, and M. Bustin
HMGN3a and HMGN3b, Two Protein Isoforms with a Tissue-specific Expression Pattern, Expand the Cellular Repertoire of Nucleosome-binding Proteins
J. Biol. Chem.,
July 6, 2001;
276(28):
25959 - 25969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kaczynski, J.-S. Zhang, V. Ellenrieder, A. Conley, T. Duenes, H. Kester, B. van der Burg, and R. Urrutia
The Sp1-like Protein BTEB3 Inhibits Transcription via the Basic Transcription Element Box by Interacting with mSin3A and HDAC-1 Co-repressors and Competing with Sp1
J. Biol. Chem.,
September 21, 2001;
276(39):
36749 - 36756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
