 | CHARCOT-MARIE-TOOTH DISORDERS
Copyright © 1999 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 883:42-46 (1999)
© 1999 New York Academy of Sciences
Charcot-Marie-Tooth Disease Type 2
JEFFERY M. VANCEa
Division of Neurology, Department of Medicine, Duke University Medical Center, Box 2903, Durham, North Carolina 27710, USA
aAddress for correspondence: 919-681-5696 (voice); 919-681-7894 (fax); jeff{at}dnadoc.mc.duke.edu (e-mail).
No unique genes have yet been found for CMT2, but both Cx32 and P 0 appear to contribute to the phenotype. Not surprisingly, CMT2 is likely to display much more genetic heterogeneity than CMT1. However, it is also likely continue to challenge previous concepts on classification and relationship of traditional inherited phenotypes in neurology. Future work on CMT2 should produce insight not only into the cellular interactions of the peripheral nerve especially Schwann cell and axon relationships, but also into idiopathic neuropathy.
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