 | ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN
Copyright © 1999 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 886:12-22 (1999)
© 1999 New York Academy of Sciences
A Paradigm for Cancer Treatment Using the Retinoblastoma Gene in a Mouse Model
ALEXANDER YU. NIKITINa,
DANIEL J. RILEYb AND
WEN-HWA LEEa,c
aDepartment of Molecular Medicine/Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245-3207, USA
bDepartment of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78245-3207, USA
cTo whom requests for reprints should be addressed: Institute of Biotechnology, The University of Texas Health Science Center, 15355 Lambda Drive, San Antonio, Texas 78245-3207. Phone, 210/567-7351; fax, 210/567-7377.
e-mail, leew{at}uthscsa.edu
Discovery of tumor suppressor genes has provided a rational approach to cancer prevention and treatment. Loss of retinoblastoma susceptibility gene ( Rb) function is a rate-limiting event in the development of human and mouse cancers. Establishment of animal models of cancer associated with Rb deficiency allowed us to develop and test long-awaited approaches to genetic correction for treating tumors in vivo. Recent studies demonstrated that (1) prevention of carcinogenesis is achieved by correction of gene copy number in Rb+/- mice, and (2) reconstitution of Rb gene functions is sufficient for suppression of neoplasia in immunocompetent mice. These results fulfill a promise of cancer treatment by reconstitution of tumor suppressor function.
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