 | ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN
Copyright © 1999 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 886:132-157 (1999)
© 1999 New York Academy of Sciences
Activation of Apoptosis and Its Inhibition
DOUGLAS K. MILLERa
Department of Immunology and Rheumatology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
aAdress all correspondence to: Dr. Douglas K Miller, Department of Inflammation Research, Merck Research Laboratories, PO Box 200,R80N-A32, Rahway, New Jersey 07065. Phone, 908/594-6838;fax, 908/594-3111.
e-mail, douglas_miller{at}merck.com
The induction of apoptosis, or controlled cell death, by various stimuli has been shown to activate a cascade of endoproteases, called caspases, that cleave numerous cellular proteins necessary for cellular homeostasis. This review discusses this family of proteases together with a variety of mammalian and viral regulatory proteins that act to control this activation.
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