The New York Hospital-Cornell Medical Center and Strang Cancer Prevention Center, New York, New York 10021, USA
The APC protein is a crucial regulator of intestinal cell growth,
and mutations in the
APC gene are a common initial event in
the process of human colorectal carcinogenesis. animals bearing
germline mutations in
Apc are therefore important models for
human colorectal cancer. these animals have been used both to
understand the biology of human colorectal cancer and to screen
for agents able to prevent malignant transformation of susceptible
intestinal cells.
