 | THE YOUNG WOMAN AT THE RISE OF THE 21st CENTURY GYNECOLOGICAL AND REPRODUCTIVE ISSUES IN HEALTH AND DISEASE
Copyright © 2000 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 900:174-183 (2000)
© 2000 New York Academy of Sciences
Role of Leptin in Reproduction
CHRISTOS S. MANTZOROSa
Division of Endocrinology, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
aAddress for correspondence: C.S. Mantzoros, MD, DSc, Division of Endocrinology, RN 325, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. Phone: 617-667-2151; fax: 617-667-2927.
cmantzor{at}caregroup.harvard.edu
Leptin is a 16-kDa adipocyte-secreted protein the serum levels of which reflect mainly the amount of energy stores but are also influenced by short-term energy imbalance as well as several cytokines and hormones. Leptin, by binding to specific receptors, alters the expression of several hypothalamic neuropeptides that regulate neuroendocrine function as well as energy intake and expenditure. More specifically, accumulating evidence suggests that this hormone may serve to signal to the brain information on the critical amount of fat stores that are necessary for LHRH secretion and activation of the hypothalamic-pituitary-gonadal axis. Rising leptin levels have been associated with initiation of puberty in animals and humans and normal leptin levels are needed for maintenance of menstrual cycles and normal reproductive function. Moreover, circadian and ultradian variations of leptin levels are associated with minute to minute variations of LH and estradiol in normal women. Falling leptin levels in response to starvation result in decreased estradiol levels and amenorrhea in subjects with anorexia nervosa or strenuously exercising athletes. In addition, leptin has a potentially important role during pregnancy and in the physiology of the neonate. Finally, recent evidence suggests that leptin may influence ovarian steroidogenesis directly, but the exact role of intra-ovarian leptin action in the physiology and pathophysiology of the human reproductive system needs to be further elucidated.
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|
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|
|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal
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February 15, 2005;
102(7):
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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