 | LYSOPHOSPHOLIPIDS AND EICOSANOIDS IN BIOLOGY AND PATHOPHYSIOLOGY
Copyright © 2000 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 905:11-15 (2000)
© 2000 New York Academy of Sciences
Group IV Cytosolic Phospholipase A2 Activation by Diacylglycerol Pyrophosphate in Murine P388D1 Macrophages
JESÚS BALSINDE,
MARÍA A. BALBOA AND
EDWARD A. DENNISa
Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093-0601, USA
aCorresponding author. Voice: 858/534-3055; fax: 858/534-7390.
edennis{at}ucsd.edu
Diacylglycerol pyrophosphate (DGPP) is a novel phospholipid identified in yeast, bacteria, and plants, but not yet in mammalian cells. Given its structural resemblance to other phospholipid-activating molecules, such as lysophosphatidate, phosphatidate, and diacylglycerol, it was questioned whether DGPP was capable of activating macrophages to release arachidonic acid (AA) metabolites such as the prostaglandins. It has been found that DGPP is able to potently stimulate prostaglandin production in the murine cell line P388D 1 by a mechanism that involves activation of the cytosolic Group IV phospholipase A 2 (cPLA 2). Our results demonstrate that DGPP possesses macrophage-activating-factor properties and suggest a role for this novel compound in the inflammatory response.
This article has been cited by other articles:
|
|
|
|
 
T. W. Stief
Thrombin Generation by Exposure of Blood to Endotoxin: A Simple Model to Study Disseminated Intravascular Coagulation
Clinical and Applied Thrombosis/Hemostasis,
April 1, 2006;
12(2):
137 - 161.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. Brant and R. Loch Caruso
Late-Gestation Rat Myometrial Cells Express Multiple Isoforms of Phospholipase A2 That Mediate PCB 50-Induced Release of Arachidonic Acid with Coincident Prostaglandin Production
Toxicol. Sci.,
November 1, 2005;
88(1):
222 - 230.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Pawliczak, C. Logun, P. Madara, M. Lawrence, G. Woszczek, A. Ptasinska, M. L. Kowalski, T. Wu, and J. H. Shelhamer
Cytosolic Phospholipase A2 Group IV{alpha} but Not Secreted Phospholipase A2 Group IIA, V, or X Induces Interleukin-8 and Cyclooxygenase-2 Gene and Protein Expression through Peroxisome Proliferator-activated Receptors {gamma} 1 and 2 in Human Lung Cells
J. Biol. Chem.,
November 19, 2004;
279(47):
48550 - 48561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Idzko, M. Laut, E. Panther, S. Sorichter, T. Durk, J. W. Fluhr, Y. Herouy, M. Mockenhaupt, D. Myrtek, P. Elsner, et al.
Lysophosphatidic Acid Induces Chemotaxis, Oxygen Radical Production, CD11b Up-Regulation, Ca2+ Mobilization, and Actin Reorganization in Human Eosinophils via Pertussis Toxin-Sensitive G Proteins
J. Immunol.,
April 1, 2004;
172(7):
4480 - 4485.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
