 | MOLECULAR AND CELLULAR GERONTOLOGY
Copyright © 2000 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 908:133-142 (2000)
© 2000 New York Academy of Sciences
Aging and Longevity: A Paradigm of Complementation between Homeostatic Mechanisms and Genetic Control?
CHARIKLIA PETROPOULOU,
NIKI CHONDROGIANNI,
DAVINA SIMÕES,
GEORGIA AGIOSTRATIDOU,
NATALIA DROSOPOULOS,
VIOLETTA KOTSOTA AND
EFSTATHIOS S. GONOSa
Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens 116 35, Greece
aAddress for correspondence: Efstathios S. Gonos, Ph.D., Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas. Constantinou Avenue, Athens 116 35, Greece. Phone: 30 1 7273756; fax: 30 1 7251827.
sgonos{at}eie.gr
Aging is a universal and inevitable phenomenon that affects nearly all animal species. It can be considered the product of an interaction between genetic, environmental, and lifestyle factors, which in turn influence longevity that varies between and within species. It has been proposed not only that the aging process is under genetic control, but that it can also be considered a result of the failure of homeostasis due to the accumulation of damage. This review article discusses these issues, focusing on the function of genes that associate with aging and longevity, as well as on the molecular mechanisms that control cell survival and maintenance during aging.
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