 | MOLECULAR AND CELLULAR GERONTOLOGY
Copyright © 2000 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 908:50-63 (2000)
© 2000 New York Academy of Sciences
Genetics of Human Aging: The Search for Genes Contributing to Human Longevity and Diseases of the Old
P. ELINE SLAGBOOMa,b,
BASTIAAN T. HEIJMANSb,c,
MARIAN BEEKMANd,
RUDI G.J. WESTENDORPc AND
INGRID MEULENBELTb
bGaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
cSection of Gerontology and Geriatrics, Department of General Medicine, Leiden University Medical Centre, Leiden, The Netherlands
dDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands
aAddress for correspondence: P. Eline Slagboom, TNO-PG, Department of Vascular and Connective Tissue Research, Leiden, The Netherlands.
p.slagboom{at}pg.tno.nl
An aging population of humans reflects early-onset morbidity and mortality as well as late-onset disease in the phase when the mortality rate doubles and, finally, longevity of extremely long-lived subjects. Genetic influences have been reported to be relevant for each of these three phases. A growing field in genetic research is aimed at the identification of genes involved in multi-factorial diseases of the old and in longevity. Important issues in these studies include the definition of phenotype, which maximally highlights the genetic contribution, whether earlier and later onset phenotypes have loci in common, and how to rank or reject the many candidate disease loci found in different studies. These issues will be illustrated from research on cardiovascular disease and osteoarthritis.
This article has been cited by other articles:
|
|
|
|
 
B Jani and C Rajkumar
Ageing and vascular ageing.
Postgrad. Med. J.,
June 1, 2006;
82(968):
357 - 362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Beekman, G. J. Blauw, J. J. Houwing-Duistermaat, B. W. Brandt, R. G. J. Westendorp, and P. E. Slagboom
Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.
J. Gerontol. A Biol. Sci. Med. Sci.,
April 1, 2006;
61(4):
355 - 362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Deocaris, S. C. Kaul, K. Taira, and R. Wadhwa
Emerging Technologies: Trendy RNA Tools for Aging Research
J. Gerontol. A Biol. Sci. Med. Sci.,
August 1, 2004;
59(8):
B771 - B783.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Loughlin, B. Dowling, K. Chapman, L. Marcelline, Z. Mustafa, L. Southam, A. Ferreira, C. Ciesielski, D. A. Carson, and M. Corr
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females
PNAS,
June 29, 2004;
101(26):
9757 - 9762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. Newman, A. M. Arnold, B. L. Naydeck, L. P. Fried, G. L. Burke, P. Enright, J. Gottdiener, C. Hirsch, D. O'Leary, and R. Tracy
"Successful Aging": Effect of Subclinical Cardiovascular Disease
Arch Intern Med,
October 27, 2003;
163(19):
2315 - 2322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Mahler
Mutant Models of Prolonged Life Span
Toxicol Pathol,
October 1, 2001;
29(6):
673 - 676.
[Abstract]
[PDF]
|
|
|
|
