 | THE PARAHIPPOCAMPAL REGION: IMPLICATIONS FOR NEUROLOGICAL AND PSYCHIATRIC DISEASES
Copyright © 2000 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 911:392-403 (2000)
© 2000 New York Academy of Sciences
Networks of the Hippocampal Memory System of the Rat: The Pivotal Role of the Subiculuma
PIETERKE A. NABERb,c,d,
MENNO P. WITTERd AND
FERNANDO H. LOPES DA SILVAc
Graduate School Neurosciences Amsterdam
cInstitute of Neurobiology, University of Amsterdam
dInstitute of Neurosciences, Department of Anatomy, Free University, Amsterdam, the Netherlands
aThis research was supported by Grant No. 903-47-008 of The Netherlands Organization for Scientific Research (NWO) and the Human Frontier Science Program.
bCurrent address: Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, the Netherlands. Tel.: +31 20 5665495; fax: +31 20 6961006.
e-mail: R.Naber{at}nih.knaw.nl
The hippocampal system, consisting of the hippocampus, subiculum, and adjacent parahippocampal region, is known to play an important role in learning and memory processes. It is also known that the originally proposed trisynaptic circuit is a simplified representation of the organization of this system. In this paper, we present evidence, both anatomically and electrophysiologically, for the existence of direct and indirect parallel pathways through the hippocampal memory system arising from the perirhinal and postrhinal cortex. These pathways form nested loops. The subiculum occupies a central position within these loops. In the subiculum, both "raw" and highly processed information will converge. Therefore, we propose that the subiculum occupies a pivotal position in the hippocampal memory system, both as recipient and comparator of signals and as a distributor of processed information.
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