 | ALZHEIMER'S DISEASE: A COMPENDIUM OF CURRENT THEORIES
Copyright © 2000 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 924:170-183 (2000)
© 2000 New York Academy of Sciences
The Mitochondrial Spiral: An Adequate Cause of Dementia in the Alzheimer's Syndrome
JOHN P. BLASSa
Burke Medical Research Institute, Weill-Cornell Medical College, White Plains, New York 10605, USA
aAddress for correspondence: Dr. John P. Blass, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, New York 10605. Voice: 914-597-2351; fax: 914-597-2757.
jpblass{at}mail.med.cornell.edu
A variety of chronic, relatively low-grade injuries to the brain occur in Alzheimer's disease (AD). The extent to which each of these contributes to the clinical syndrome is unclear. Several of the abnormalities that occur in AD brain can cause dementia by themselves, even in people who do not have the neuropathological hallmarks of AD. Prominent among these abnormalities is a deleterious "mitochondrial spiral," which consists of reduced brain metabolism, oxidative stress, and calcium dysregulation. The hypothesis presented in this paper is that the mitochondrial spiral contributes to dementia in AD and presents a reasonable target for the development of new approaches to the treatment of this syndrome.
Key Words: Mitochondria • Energy • KGDHC • Reactive oxygen species • Calcium
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