ALZHEIMER'S DISEASE: A COMPENDIUM OF CURRENT THEORIES
Copyright © 2000 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 924:39-41 (2000)
© 2000 New York Academy of Sciences
Synaptic Structure and Function in Transgenic APP Mice
KAREN HSIAO ASHEa
Department of Neurology, University of Minnesota, Minneapolis, Minnesota 55455, USA
aAddress for correspondence: Dr. Karen Hsiao Ashe, Department of Neurology, University of Minnesota, Box 295 UMHC, 420 Delaware Street S.E., Minneapolis, Minnesota 55455. Voice: 612-626-0652; fax: 612-626-2639.
e-mail: hsiao005{at}tc.umn.edu
Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.
Key Words: Transgenic APP mice • Synaptic structure (murine) • Amyloid precursor protein
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