 | NEURO-CARDIOVASCULAR REGULATION: From Molecules to Man
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 940:132-141 (2001)
© 2001 New York Academy of Sciences
Cellular Mechanisms of Baroreceptor Integration at the Nucleus Tractus Solitarius
MICHAEL C. ANDRESEN,
MARK W. DOYLE,
YOUNG-HO JIN AND
TIMOTHY W. BAILEY
Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
Address for correspondence: Dr. Michael C. Andresen, Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, Oregon 97201-3098. Voice: 503-494-5831; fax: 503-494-4352
andresen{at}OHSU.edu
The autonomic nervous system makes important contributions to the homeostatic regulation of the heart and blood vessels through arterial baroreflexes, and yet our understanding of the central nervous system mechanisms is limited. The sensory synapse of baroreceptors in the nucleus tractus solitarius (NTS) is unique because its participation is obligatory in the baroreflex. Here we describe experiments targeting this synapse to provide greater understanding of the cellular mechanisms at the earliest stages of the baroreflex. Our approach utilizes electrophysiology, pharmacology, and anatomical tracers to identify and evaluate key elements of the sensory information processing in NTS.
Key Words: Baroreceptor • Baroreflex • Glutamate • Visceral sensory • Nucleus of the solitary tract • Synaptic processing
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