 | NEURO-CARDIOVASCULAR REGULATION: From Molecules to Man
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 940:247-258 (2001)
© 2001 New York Academy of Sciences
Excitatory Inputs to the RVLM in the Context of the Baroreceptor Reflex
ALAN F. SVEDa,
SATORU ITOb,
CHRISTOPHER J. MADDENa,
SEAN D. STOCKERa AND
YOSHIHARU YAJIMAa
aDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
bSecond Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
Address for correspondence: Dr. Alan F. Sved, Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260. Voice: 412-624-6996; fax: 412-624-9198.
sved{at}bns.pitt.edu
The central neural circuit mediating baroreceptor control of sympathetic vasomotor outflow involves an excitatory projection from arterial baroreceptors to nucleus tractus solitarius, an excitatory projection from nucleus tractus solitarius to the caudal ventrolateral medulla, an inhibitory projection from the caudal ventrolateral medulla to the rostral ventrolateral medulla (RVLM), and an excitatory projection from the RVLM to sympathetic preganglionic neurons in the spinal cord. For this circuit to be operational, the relevant neurons in the RVLM must be tonically active. Indeed, numerous studies have demonstrated that RVLM vasomotor neurons are tonically active; however, little is known regarding the nature of the tonic excitatory drive to these neurons. We present a model in which RVLM vasomotor neurons are tonically excited by inputs to the RVLM that can be blocked by the excitatory amino acid receptor antagonist, kynurenic acid, as well as an input from the caudal ventrolateral medulla that is not sensitive to kynurenic acid.
Key Words: Rostral ventrolateral medulla • Caudal ventrolateral medulla • Caudal pressor area • Excitatory amino acids • Sarthran
This article has been cited by other articles:
|
|
|
|
 
J. M. Adams, C. J. Madden, A. F. Sved, and S. D. Stocker
Increased Dietary Salt Enhances Sympathoexcitatory and Sympathoinhibitory Responses From the Rostral Ventrolateral Medulla
Hypertension,
August 1, 2007;
50(2):
354 - 359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. Stocker, R. Meador, and J. M. Adams
Neurons of the Rostral Ventrolateral Medulla Contribute to Obesity-Induced Hypertension in Rats
Hypertension,
March 1, 2007;
49(3):
640 - 646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Iigaya, H. Kumagai, H. Onimaru, A. Kawai, N. Oshima, T. Onami, C. Takimoto, T. Kamayachi, K. Hayashi, T. Saruta, et al.
Novel axonal projection from the caudal end of the ventrolateral medulla to the intermediolateral cell column
Am J Physiol Regulatory Integrative Comp Physiol,
February 1, 2007;
292(2):
R927 - R936.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Schreihofer, S. Ito, and A. F. Sved
Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats
Am J Physiol Regulatory Integrative Comp Physiol,
December 1, 2005;
289(6):
R1746 - R1755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. F. Sved
Tonic glutamatergic drive of RVLM vasomotor neurons?
Am J Physiol Regulatory Integrative Comp Physiol,
December 1, 2004;
287(6):
R1301 - R1303.
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. L. Brooks, K. L. Freeman, and K. A. Clow
Excitatory amino acids in rostral ventrolateral medulla support blood pressure during water deprivation in rats
Am J Physiol Heart Circ Physiol,
May 1, 2004;
286(5):
H1642 - H1648.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-C. Huang, S. H. H. Chan, and K.-S. Hsu
cGMP/Protein Kinase G-Dependent Potentiation of Glutamatergic Transmission Induced by Nitric Oxide in Immature Rat Rostral Ventrolateral Medulla Neurons in Vitro
Mol. Pharmacol.,
August 1, 2003;
64(2):
521 - 532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
