 | THE VESTIBULAR LABYRINTH IN HEALTH AND DISEASE
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 942:274-286 (2001)
© 2001 New York Academy of Sciences
Physiology of the Semicircular Canals after Surgical Plugging
R. D. RABBITTa,d,
R. BOYLEb,d AND
S. M. HIGHSTEINc,d
aDepartment of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
bNASA Ames Center for Bioinformatics, Moffett Field, California 94035, USA
cDepartments of Otolaryngology and Neurobiology, Washington University, St. Louis, Missouri 63110, USA
dMarine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
Address for correspondence: Richard D. Rabbitt, 2480 MEB, Dept. of Bioengineering, 50 South Central Campus Drive, University of Utah, Salt Lake City, UT 84112. Voice: (801) 581-6968; fax: (801) 585-5361.
r.rabbitt{at}utah.edu
Inactivation of individual semicircular canals by surgical occlusion (plugging) of the slender duct has been used in basic studies to elucidate the role of individual canal inputs to vestibular-mediated control systems and in clinical applications to treat certain vestibular disorders. The procedure has been shown to be highly effective in blocking sensitivity of individual canals, at least for moderate angular motion stimuli. Effectiveness does not extend to stimuli involving high accelerations where a residual response persists even after complete occlusion of the duct. The residual can be quite large at high-stimulus frequencies where sensitivity to angular motion approaches that of patent canals. The overall physiological effect of canal plugging is reported here in terms of the frequency-dependent attenuation in gain and phase shift of primary afferents. Plug-canal responses are quantitatively described in terms of biomechanics of the deformable labyrinth.
Key Words: Vestibular • Biomechanics • Afferent • BPPV • Endolymph • Occlusion
This article has been cited by other articles:
|
|
|
|
 
A. F. Mensinger and M. E. Tubbs
Effects of Temperature and Diet on the Growth Rate of Year 0 Oyster Toadfish, Opsanus tau.
Biol. Bull.,
February 1, 2006;
210(1):
64 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Rabbitt, R. Boyle, G. R. Holstein, and S. M. Highstein
Hair-Cell Versus Afferent Adaptation in the Semicircular Canals
J Neurophysiol,
January 1, 2005;
93(1):
424 - 436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Arai, S. B. Yakushin, B. Cohen, J.-I. Suzuki, and T. Raphan
Spatial Orientation of Caloric Nystagmus in Semicircular Canal-Plugged Monkeys
J Neurophysiol,
August 1, 2002;
88(2):
914 - 928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
