 | HUMAN FERTILITY AND REPRODUCTION: THE OOCYTE, THE EMBRYO, AND THE UTERUS
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 943:49-54 (2001)
© 2001 New York Academy of Sciences
Gonadotropin-Releasing Hormone Antagonists
Implications for Oocyte Quality and Uterine Receptivity
KEITH GORDON
Reproductive Medicine, Organon Inc., West Orange, New Jersey 07052, USA
Address for correspondence: Keith Gordon, Ph.D., Associate Director, Reproductive Medicine, Organon Inc., 375 Mt. Pleasant Ave., West Orange, NJ 07052. Voice: 973-325-5403; fax: 973-325-4699.
k.gordon{at}organoninc.com
Until recently, gonadotropin-releasing hormone (GnRH) agonists were the only choice available to physicians for prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The recent FDA approval of GnRH antagonists for this indication gives clinicians some new options. Results of clinical trials to date suggest that, with GnRH antagonists, much shorter treatment regimens with fewer injections and possibly less gonadotropin can achieve good clinical results. In most of the trials performed to date, however, the GnRH antagonist regimens have been associated with a slightly lower pregnancy and implantation rate than the established GnRH agonist protocols. This remains the biggest hurdle to their more general acceptance. Herein, the possible contributing factors are discussed, and the proposal made that differences in serum estradiol patterns preceding oocyte retrieval are the most likely contributing factor.
Key Words: GnRH antagonist • controlled ovarian (hyper)stimulation • in vitro fertilization/embryo transfer • uterine receptivity
This article has been cited by other articles:
|
|
|
|
 
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev.,
April 1, 2006;
27(2):
170 - 207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Mirkin, G. Nikas, J.-G. Hsiu, J. Diaz, and S. Oehninger
Gene Expression Profiles and Structural/Functional Features of the Peri-Implantation Endometrium in Natural and Gonadotropin-Stimulated Cycles
J. Clin. Endocrinol. Metab.,
November 1, 2004;
89(11):
5742 - 5752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Endo, H. Honnma, T. Hayashi, M. Chida, K. Yamazaki, Y. Kitajima, A. Azumaguchi, H. Kamiya, and R. Kudo
Continuation of GnRH agonist administration for 1 week, after hCG injection, prevents ovarian hyperstimulation syndrome following elective cryopreservation of all pronucleate embryos
Hum. Reprod.,
October 1, 2002;
17(10):
2548 - 2551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
