 | CIRCULATING NUCLEIC ACIDS IN PLASMA OR SERUM II
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 945:119-131 (2001)
© 2001 New York Academy of Sciences
Fetomaternal Cellular and Plasma DNA Trafficking
The Yin and the Yang
DIANA W. BIANCHIa AND
Y. M. DENNIS LOb
aDivision of Genetics and Departments of Pediatrics and Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts, USA
bDepartment of Chemical Pathology and Institute of Molecular Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
Address for correspondence—either: Diana W. Bianchi, Division of Genetics and Departments of Pediatrics and Obstetrics and Gynecology, Tufts University School of Medicine, 750 Washington Street, Box 394, Boston, MA 02111. Voice: 617-636-1468; fax: 617-636-1469.
dbianchi{at}lifespan.org
or Y. M. Dennis Lo, Department of Chemical Pathology, Room 38023, 1/F Clinical Sciences Building, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong Special Administrative Region, China. Voice: +852 2632 2563; fax: +852 2194 6171.
loym{at}cuhk.edu.hk
In human pregnancy, multiple lines of evidence have indicated that there is trafficking of nucleated cells and cell-free DNA between the mother and fetus. Diagnostically, fetal cells in maternal blood and fetal DNA in maternal plasma offer a noninvasive source of fetal material for prenatal diagnosis. Through the developments of methods for fetal cell isolation and fetal DNA detection, many fetal genetic characteristics and chromosomal abnormalities have been detected from maternal blood. Large-scale clinical trials have been initiated that will facilitate the eventual application of these technologies. The presence of large quantities of cell-free fetal DNA in maternal plasma challenges the conventional belief that the fetal and maternal circulations are separate entities. In addition, the recent demonstration of the persistence of fetal cells following delivery also opens up a new field of investigation and raises new physiologic and pathogenic implications. Like the Yin and Yang in Chinese mythology, we believe that fetal cells and fetal DNA transfer are closely related and should be studied and applied in a synergistic manner.
Key Words: Noninvasive prenatal diagnosis • Chimerism • Genetic diagnosis
This article has been cited by other articles:
|
|
|
|
 
A. Fernandez, B. Prieto, A. Escudero, J. H. Ladenson, and F. V. Alvarez
A Monoclonal Antibody with Potential for Aiding Non-invasive Prenatal Diagnosis: Utility in Screening of Pregnant Women at Risk of Preeclampsia
J. Histochem. Cytochem.,
March 1, 2005;
53(3):
345 - 350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. WISSLER
Extracellular and Circulating Redox- and Metalloregulated eRNA and eRNP: Copper Ion-Structured RNA Cytokines (Angiotropin Ribokines) and Bioaptamer Targets Imparting RNA Chaperone and Novel Biofunctions to S100-EF-Hand and Disease-Associated Proteins
Ann. N.Y. Acad. Sci.,
June 1, 2004;
1022(1):
163 - 184.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Masuzaki, K Miura, K-i Yoshiura, S Yoshimura, N Niikawa, and T Ishimaru
Detection of cell free placental DNA in maternal plasma: direct evidence from three cases of confined placental mosaicism
J. Med. Genet.,
April 1, 2004;
41(4):
289 - 292.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Smid, S. Galbiati, A. Vassallo, D. Gambini, A. Ferrari, G. Restagno, E. Viora, M. Pagliano, S. Calza, M. Ferrari, et al.
Fetal DNA in Maternal Plasma in Twin Pregnancies
Clin. Chem.,
September 1, 2003;
49(9):
1526 - 1528.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. O'Donoghue, M. Choolani, J. Chan, J. de la Fuente, S. Kumar, C. Campagnoli, P.R. Bennett, I.A.G. Roberts, and N.M. Fisk
Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis
Mol. Hum. Reprod.,
August 1, 2003;
9(8):
497 - 502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Y. Zhong, W. Holzgreve, and S. Hahn
Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts
Mol. Hum. Reprod.,
September 1, 2002;
8(9):
864 - 870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
