 | ENVIRONMENTAL HORMONES: THE SCIENTIFIC BASIS OF ENDOCRINE DISRUPTION
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 948:112-120 (2001)
© 2001 New York Academy of Sciences
Estrogen-Associated Genes in Uterine Leiomyoma
SHUANFANG LI AND
JOHN A. McLACHLAN
Department of Pharmacology, Tulane University, and Center for Bioenvironmental Research at Tulane & Xavier Universities, SL-3, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
Address for correspondence: Dr. John A. McLachlan, Center for Bioenvironmental Research at Tulane/Xavier Universities, SL-3, 1430 Tulane Avenue, New Orleans, LA 70112-2699. Voice: 504-585-6910; fax: 504-585-6428.
john.mclachlan{at}tulane.edu
Uterine leiomyomas or fibroids are classified as a benign uterine disease in that the polyps display no malignant growth. However, uterine leiomyomas are a leading cause of morbidity, infertility, and hysterectomy in women. Since leiomyomas are known to be sensitive to estrogen for their growth, we have examined uterine genes known to be estrogen responsive in affected and unaffected uterine tissue. This information will be useful in determining the contribution, if any, of hormonally active environmental chemicals to this highly prevalent reproductive disorder.
Key Words: estrogen • estrogen receptor • leiomyoma • pregnancy • tumor • uterine leiomyoma
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