 | SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMs)
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 949:223-234 (2001)
© 2001 New York Academy of Sciences
Estrogen Replacement Therapy for the Potential Treatment or Prevention of Alzheimer's Disease
MARILYN M. MILLER,
ANDREW A. MONJAN AND
NEIL S. BUCKHOLTZ
Neuroscience and Neuropsychology of Aging Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
Address for correspondence:, Neil S. Buckholtz, Ph.D., Neuroscience and Neuropsychology of Aging Program, National Institute on Aging, 7201 Wisconsin Avenue, Gateway Building Suite 3C307 MSC 9205, Bethesda, Maryland 20892-9205. Voice: 301-496-9350; fax: 301-496-1494.
BuckholN{at}nia.nih.gov
Alzheimer's disease (AD) is an irreversible, progressive brain disorder that occurs gradually and results in memory loss, behavior and personality changes, and a decline in cognitive abilities. Although basic biological data suggest that estrogen may have neuroprotective and neuroenhancing functions, a number of studies have produced conflicting findings on the use of estrogen for maintaining cognitive function in older people. This review summarizes clinical studies that have examined the effects of estrogen in women with AD.
Key Words: Alzheimer's disease • estrogen • cognitive function • clinical trials • epidemiology • memory
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