 | WEST NILE VIRUS: DETECTION, SURVEILLANCE, AND CONTROL
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 951:195-206 (2001)
© 2001 New York Academy of Sciences
Variations in Biological Features of West Nile Viruses
V. DEUBELa,
L. FIETTEb,
P. GOUNONb,
M. T. DROUETb,
H. KHUNb,
M. HUERREb,
C. BANETc,
M. MALKINSONc AND
P. DESPRÈSb
aInstitut Pasteur, Lyon, France
bInstitut Pasteur, Paris, France
cKimron Veterinary Institute, Beit Dagan, Israel
Address for correspondence: V. Deubel, Institut Pasteur, Unité de Biologie des Infections Virales Emergentes, 21 Avenue Tony Garnier, 69365 Lyon cedex 7, France. Voice: +33-437-282-442; fax: +33-437-282-441.
vdeubel{at}cervi-lyon.inserm.fr
Pathological findings in humans, horses, and birds with West Nile (WN) encephalitis show neuronal degeneration and necrosis in the central nervous system (CNS), with diffuse inflammation. The mechanisms of WN viral penetration of the CNS and pathophysiology of the encephalitis remain largely unknown. Since 1996, several epizootics involving hundreds of humans, horses, and thousands of wild and domestic bird cases of encephalitis and mortality have been reported in Europe, North Africa, the Middle East, Russia, and the USA (see specific chapters in this issue). However, biological and molecular markers of virus virulence should be characterized to assess whether novel strains with increased virulence are responsible for this recent proliferation of outbreaks.
Key Words: West Nile virus • central nervous system • flavivirus infection
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