 | CANCER PREVENTION: MOLECULAR MECHANISMS TO CLINICAL APPLICATIONS
Copyright © 2001 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 952:73-87 (2001)
© 2001 New York Academy of Sciences
Cellular Mechanisms of Calcium and Vitamin D in the Inhibition of Colorectal Carcinogenesis
SERGIO A. LAMPRECHT AND
MARTIN LIPKIN
Strang Cancer Prevention Center, New York, New York 10021, USA
Address for correspondence: Dr. M. Lipkin, Strang Cancer Research Laboratory at the Rockefeller University, 1230 York Avenue, New York, NY 10021.
Convincing evidence is available showing that dietary calcium and vitamin D impede the development of colonic carcinogenesis. The major cellular modes of action of calcium and vitamin D which can contribute to the inhibition of colonic neoplasia are reviewed in this article. These consist of complex series of signaling events induced by the chemopreventive agents acting at various tiers of colonic cell organization.
Key Words: calcium • vitamin D • colon cancer
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