 | NEUROBIOLOGY OF EYE MOVEMENTS: FROM MOLECULES TO BEHAVIOR
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 956:380-390 (2002)
© 2002 New York Academy of Sciences
A Neurobiological Approach to Acquired Nystagmus
R. JOHN LEIGHa,
VALLABH E. DASb AND
SCOTT H. SEIDMANc
aNeurology Service, Veterans Affairs Medical Center and Case Western University, Cleveland, Ohio 44106, USA
bEmory University, Atlanta, Georgia 30322, USA
cUniversity of Rochester Medical Center, Rochester, New York 14642, USA
Address for correspondence: Dr. R. John Leigh, Department of Neurology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106. Voice: 216-421-3224; fax: 216-231-3461.
rjl{at}po.cwru.edu
Ann. N.Y. Acad. Sci. 956: 380-390 (2002).
The development of animal and mathematical models for several forms of acquired nystagmus has led to more comprehensive knowledge of these disorders. In the best understood forms, such as periodic alternating nystagmus, our range of knowledge includes an animal model, the neurotransmitters involved, and effective treatment. For some other forms, such as downbeat nystagmus, we have an animal model, but reliable treatment is lacking. In other cases, exemplified by acquired pendular nystagmus, we have only a provisional hypothesis for pathogenesis to account for the oscillations, without an animal model, but effective treatment is possible in some patients. The present trend of studying all aspects of the neurobiology of nystagmus, from molecules to behavior, seems to be the best approach to extend our knowledge and to identify new treatments, but much remains to be done.
Key Words: periodic alternating nystagmus • downbeat nystagmus • pendular nystagmus • multiple sclerosis
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