 | NEUROBIOLOGY OF EYE MOVEMENTS: FROM MOLECULES TO BEHAVIOR
Copyright © 2002 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 956:85-98 (2002)
© 2002 New York Academy of Sciences
Studies of the Role of the Paramedian Pontine Reticular Formation in the Control of Head-Restrained and Head-Unrestrained Gaze Shifts
DAVID L. SPARKSa,
ELLEN J. BARTONa,
NEERAJ J. GANDHIa AND
JON NELSONb
aDivision of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
bDepartment of Physical Therapy, The College of St. Scholastica, Duluth, Minnesota 55811, USA
Address for correspondence: David L. Sparks, Ph.D., Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.
sparks{at}cns.bcm.tmc.edu.
Ann. N.Y. Acad. Sci. 956: 85-98 (2002).
Results of three experiments related to the role of the paramedian pontine reticular formation (PPRF) in the control of gaze are described. (1) Chronic unit recording methods, used to study the on-directions of short-lead burst neurons in head-restrained monkeys, and (2) reversible inactivation techniques confirmed the traditional view of the importance of PPRF in the control of horizontal eye movements. Reversible inactivation of neurons in the vicinity of identified short-lead burst neurons produced dramatic reductions in the speed of saccades to horizontal target displacements. The reductions in velocity were largely compensated for by an increase in saccade duration. Only minor, if any, effects were observed upon the velocity, duration, and amplitude of saccades to upward target displacements. (3) Microstimulation was applied to omnipause neurons to gate activity of excitatory burst neurons that discharge during coordinated eye-head movements. The microstimulation failed to noticeably slow (prevent) head movements when stimulation was applied during (prior to onset of) gaze shifts, suggesting that signals relayed to motoneurons innervating the neck muscles are not inhibited by the omnipause neurons. In other words, the desired gaze signal is parsed into eye and head pathways upstream of the excitatory burst neurons.
Key Words: saccades • PPRF • reversible inactivation • gaze • OPNs • microstimulation
This article has been cited by other articles:
|
|
|
|
 
R. P Di Fabio, C. Zampieri, and P. Tuite
Gaze Control and Foot Kinematics During Stair Climbing: Characteristics Leading to Fall Risk in Progressive Supranuclear Palsy
Physical Therapy,
February 1, 2008;
88(2):
240 - 250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. G. Walton, B. Bechara, and N. J. Gandhi
Role of the Primate Superior Colliculus in the Control of Head Movements
J Neurophysiol,
October 1, 2007;
98(4):
2022 - 2037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Cromer and D. M. Waitzman
Comparison of Saccade-Associated Neuronal Activity in the Primate Central Mesencephalic and Paramedian Pontine Reticular Formations
J Neurophysiol,
August 1, 2007;
98(2):
835 - 850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Gandhi and D. L. Sparks
Dissociation of Eye and Head Components of Gaze Shifts by Stimulation of the Omnipause Neuron Region
J Neurophysiol,
July 1, 2007;
98(1):
360 - 373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Klier, H. Wang, and J. D. Crawford
Interstitial Nucleus of Cajal Encodes Three-Dimensional Head Orientations in Fick-Like Coordinates
J Neurophysiol,
January 1, 2007;
97(1):
604 - 617.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Corneil, D. P. Munoz, and E. Olivier
Priming of Head Premotor Circuits During Oculomotor Preparation
J Neurophysiol,
January 1, 2007;
97(1):
701 - 714.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Sylvestre and K. E. Cullen
Premotor correlates of integrated feedback control for eye-head gaze shifts.
J. Neurosci.,
May 3, 2006;
26(18):
4922 - 4929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Leigh and C. Kennard
Using saccades as a research tool in the clinical neurosciences
Brain,
March 1, 2004;
127(3):
460 - 477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Martinez-Trujillo, H. Wang, and J. D. Crawford
Electrical Stimulation of the Supplementary Eye Fields in the Head-Free Macaque Evokes Kinematically Normal Gaze Shifts
J Neurophysiol,
June 1, 2003;
89(6):
2961 - 2974.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Corneil, E. Olivier, and D. P. Munoz
Neck Muscle Responses to Stimulation of Monkey Superior Colliculus. II. Gaze Shift Initiation and Volitional Head Movements
J Neurophysiol,
October 1, 2002;
88(4):
2000 - 2018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
