 | REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS
Copyright © 2002 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 961:210-215 (2002)
© 2002 New York Academy of Sciences
Bioreactors and Bioprocessing for Tissue Engineering
ANTHONY RATCLIFFEa AND
LAURA E. NIKLASONb
aAdvanced Tissue Sciences, La Jolla, California 92037, USA
bDepartments of Anesthesia and Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Address for correspondence: Laura E. Niklason, M.D., Ph.D., Departments of Anesthesia and Biomedical Engineering, Duke University, Room 136 Hudson Hall, Research Dr. @ Science Dr., Durham, NC 27708. Voice: 919-660-5149.
nikla001{at}mc.duke.edu
Ann. N.Y. Acad. Sci. 961: 210-215 (2002).
Bioreactor design in tissue engineering is complex, and at the early stages of its development. Design of biologically effective, yet scalable, devices requires intimate collaboration between engineers and biologists to ensure that all aspects are considered fully. Growth conditions, harvesting time, scale-up, storage, and sterility issues all need to be considered and incorporated into the design of bioreactors. Each tissue-engineered product will likely require individualized bioreactor design. However, without a comprehensive understanding of each of these components, bioreactor design and tissue growth to manufacture product will remain at a relatively rudimentary and limited level. Increased fundamental understanding of the issues can have a dramatic impact on the ability to generate tissue-engineered product safely, economically, and in the numbers that are required to fully address the patient populations in need.
Key Words: tissue engineering • bioreactors • organ culture
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