 | REPARATIVE MEDICINE: GROWING TISSUES AND ORGANS
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 961:78-82 (2002)
© 2002 New York Academy of Sciences
Therapeutic Potential of Implanted Tissue-Engineered Bioartificial Muscles Delivering Recombinant Proteins to the Sheep Heart
Y. LUa,
J. SHANSKYb,
M. DEL TATTOa,b,
P. FERLANDb,
S. MCGUIREb,
J. MARSZALKOWSKIb,
M. MAISHc,
R. HOPKINSc,
X. WANGa,b,
P. KOSNIKb,
M. NACKMANb,
A. LEEb,
B. CRESWICKa,b AND
H. VANDENBURGHa,b
aDepartment of Pathology, Brown University School of Medicine and Miriam Hospital, Providence, Rhode Island 02906, USA
bCell Based Delivery Incorporated, Providence, Rhode Island 02906, USA
cDepartment of Surgery, Brown University School of Medicine and Miriam Hospital, Providence, Rhode Island 02906, USA
Address for correspondence: H. Vandenburgh, c/o Cell Based Delivery Inc., 4 Richmond Square, Providence, RI 02906. Voice: 401-454-3540; fax: 401-454-3157.
herman_vandenburgh{at}brown.edu
Ann. N.Y. Acad. Sci. 961: 78-82 (2002).
Tissue-engineered primary adult sheep muscle cells genetically engineered to express either rhVEGF or rhIGF-1 secreted the bioactive proteins locally in the sheep heart for at least 30 days.
Key Words: gene therapy • tissue engineering • angiogenesis • ischemic heart disease
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