 | NITRIC OXIDE: NOVEL ACTIONS, DELETERIOUS EFFECTS, AND CLINICAL POTENTIAL
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 962:161-181 (2002)
© 2002 New York Academy of Sciences
A Critical Assessment of the Neurodestructive and Neuroprotective Effects of Nitric Oxide
SENG-KEE LEONGa,
RUN-SHENG RUANb AND
ZHI ZHANGc
aDepartment of Anatomy, National University of Singapore, Singapore
bDepartment of Otolaryncology, National University of Singapore, Singapore
cMRC Collaborative Centre, 1-3 Burtonhole Lane, Mill Hill, London, United Kingdom
Address for correspondence: Seng-Kee Leong, Department of Anatomy, National University of Singapore, Singapore 117597.
antlsk{at}nus.edu.sg
Ann. N.Y. Acad. Sci. 962: 161-181 (2002).
Whether nitric oxide is cytodestructive or cytoprotective is of obvious clinical importance. The debate on this subject in the past decade has generated much "heat and light". This paper focuses on the actions of NO on the nervous system and reexamines the controversial issue and the contribution of the authors and their colleagues in the light of recent findings. We also report new findings, critically assesses previous experimental data, and share perspectives on this important subject.
Key Words: critical assessment • neurodestructive effect • neuroprotection effect
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