 | NITRIC OXIDE: NOVEL ACTIONS, DELETERIOUS EFFECTS, AND CLINICAL POTENTIAL
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 962:195-206 (2002)
© 2002 New York Academy of Sciences
A Chemical Perspective on the Interplay Between NO, Reactive Oxygen Species, and Reactive Nitrogen Oxide Species
MICHAEL G. ESPEYa,
KATRINA M. MIRANDAa,
DOUGLAS D. THOMASa,
SANDHYA XAVIERa,
DEBORAH CITRINa,
MICHAEL P. VITEKb AND
DAVID A. WINKa
aRadiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.
bDepartment of Neurology, Duke University Medical Center, Durham, North Carolina, U.S.A.
Address for correspondence: Michael Graham Espey, Ph.D., Radiation Biology Branch, National Cancer Institute, NIH Building 10, Room B3-B69, Bethesda, MD 20892, U.S.A. Voice: 301-496-7511; fax: 301-480-2238.
sp{at}nih.gov
Ann. N.Y. Acad. Sci. 962: 195-206 (2002).
Nitric oxide (nitrogen monoxide, NO) plays a veritable cornucopia of regulatory roles in normal physiology. In contrast, NO has also been implicated in the etiology and sequela of numerous neurodegenerative diseases that involve reactive oxygen species (ROS) and nitrogen oxide species (RNOS). In this setting, NO is often viewed solely as pathogenic; however, the chemistry of NO can also be a significant factor in lessening injury mediated by both ROS and RNOS. The relationship between NO and oxidation, nitrosation, and nitration reactions is summarized. The salient factors that determine whether NO promotes, abates, or interconnects these chemistries are emphasized. From this perspective of NO chemistry, the type, magnitude, location, and duration of either ROS or RNOS reactions may be predicted.
Key Words: oxidative stress • nitrosative stress • nitration • nitrite • peroxidase
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