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Issue 963 coverHORMONE-RELATED TUMORS: NOVEL APPROACHES TO PREVENTION AND TREATMENT Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 963:268-281 (2002)
© 2002 New York Academy of Sciences

Effects of Weight Control and Physical Activity in Cancer Prevention

Role of Endogenous Hormone Metabolism

RUDOLF KAAKS AND ANNEKATRIN LUKANOVA

International Agency for Research on Cancer, 69372 Lyon Cedex 08, France

Address for correspondence: Dr. Rudolf Kaaks, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. Voice: 00 33 4 72 73 8553; fax: 00 33 4 72 73 8361.
kaaks{at}iarc.fr/lukanova@iarc.fr
Ann. N.Y. Acad. Sci. 963: 268-281 (2002).

Excess body weight and/or lack of physical activity are increasingly recognized as major risk factors for cancer of the colon, breast, endometrium, and prostate. This paper reviews the effects of excess body weight and physical inactivity on endogenous hormone metabolism (insulin, the IGF-I/IGFBP system, and sex steroids) and of endocrine alterations with risk of cancer of the endometrium, breast, prostate, and colon.

Key Words: weight control • physical activity • cancer prevention • endogenous hormone metabolism




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