 | HORMONE-RELATED TUMORS: NOVEL APPROACHES TO PREVENTION AND TREATMENT
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 963:268-281 (2002)
© 2002 New York Academy of Sciences
Effects of Weight Control and Physical Activity in Cancer Prevention
Role of Endogenous Hormone Metabolism
RUDOLF KAAKS AND
ANNEKATRIN LUKANOVA
International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
Address for correspondence: Dr. Rudolf Kaaks, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. Voice: 00 33 4 72 73 8553; fax: 00 33 4 72 73 8361. kaaks{at}iarc.fr/lukanova@iarc.fr Ann. N.Y. Acad. Sci. 963: 268-281 (2002).
Excess body weight and/or lack of physical activity are increasingly recognized as major risk factors for cancer of the colon, breast, endometrium, and prostate. This paper reviews the effects of excess body weight and physical inactivity on endogenous hormone metabolism (insulin, the IGF-I/IGFBP system, and sex steroids) and of endocrine alterations with risk of cancer of the endometrium, breast, prostate, and colon.
Key Words: weight control physical activity cancer prevention endogenous hormone metabolism
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