 | THE CHROMAFFIN CELL: TRANSMITTER BIOSYNTHESIS, STORAGE, RELEASE, ACTIONS, AND INFORMATICS: 11th INTERNATIONAL SYMPOSIUM ON CHROMAFFIN CELL BIOLOGY
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 971:294-299 (2002)
© 2002 New York Academy of Sciences
Neuropeptides and Chromogranins
Session Overview
ANDREA LASLOPa AND
SUSHIL K. MAHATAb
aDepartment of Pharmacology, University of Innsbruck, Peter-Mayr Strasse 1A, A-6020 Innsbruck, Austria
bDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0838, USA
Address for correspondence: Andrea Laslop, Department of Pharmacology, University of Innsbruck, Peter-Mayr Strasse 1A, A-6020 Innsbruck, Austria. Voice: +43-512-507-3703; fax: +43-512-507-2868.
andrea.laslop{at}uibk.ac.at
Ann. N.Y. Acad. Sci. 971: 294-299 (2002).
In large dense core vesicles, also referred to as chromaffin granules in adrenomedullary chromaffin cells, transmitters or hormones are stored together with neuropeptides and chromogranins. For most neuropeptides, functions have been established and new findings on their secretion, receptors, and synthesis regulation are reported. The functions of chromogranins are less clear, and possible roles as peptide precursors, Ca 2+ regulators, inducers of secretory granule biogenesis, and as nuclear constituents are discussed.
Key Words: chromaffin granule • large dense core vesicle • neuroendocrine cells • neuropeptides • chromogranin • secretogranin • regulated secretion
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