 | CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 973:573-585 (2002)
© 2002 New York Academy of Sciences
Intercellular Adhesion Molecule-1 in the Heart
HANS W. M. NIESSENa,b,
PAUL A. J. KRIJNENa,b,
CEES A. VISSERb,c,
CHRIS J. L. M. MEIJERa AND
C. ERIK HACKb,d,e
aDepartment of Pathology, bICaR-VU, cDepartment of Cardiology, and dDepartment of Clinical Chemistry, VU University Medical Center, Amsterdam, the Netherlands
eDepartment of Immunopathology, Sanquin Research at CLB, Amsterdam, the Netherlands
Address for correspondence: Hans W.M. Niessen, Department of Pathology, VU University Medical Center, Room OE16, De Boelelaan 1117, 1007 MB Amsterdam, the Netherlands. Voice: +31.20.444.4003; fax: +31.20.444.2964.
jwm.niessen{at}vumc.nl
Ann. N.Y. Acad. Sci. 973: 573-585 (2002).
Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1—for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.
Key Words: heart • ICAM-1 • acute myocardial infarction
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