 | CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 973:88-90 (2002)
© 2002 New York Academy of Sciences
Hepatic Insulin-like Growth Factor-I Binding Protein 3 Gene Expression in Rats with Endotoxic Shock: The Role of Glucocorticoids
T. PRIEGO,
I. IBAÑEZ DE CÁCERES,
A. I. MARTÍN,
M. A. VILLANÚA AND
A. LÓPEZ-CALDERÓN
Department of Physiology, Faculty of Medicine, Complutense University, 28040, Madrid, Spain
Department of Morphology and Physiology, Europea University, 28670 Madrid, Spain
Address for correspondence: A. López-Calderón, Department of Physiology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain. Voice: 00 34 91 394 1491; fax: 00 34 91 394 1628.
ALC{at}med.ucm.es
Ann. N.Y. Acad. Sci. 973: 88-90 (2002).
The aim of this work was to study the role of glucocorticoids in the insulin-like growth factor binding protein (IGFBP)-3 response to endotoxin. Lipopolysaccharide (LPS) administration decreased IGFBP-3 serum levels as well as hepatic IGFBP-3 gene expression in both adrenalectomized and sham-operated rats. These data suggest that the decrease in hepatic IGFBP-3 gene expression induced by LPS is not mediated by glucocorticoids.
Key Words: IGFBP-3 • endotoxic shock • glucocorticoids
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