 | CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 973:91-93 (2002)
© 2002 New York Academy of Sciences
Further Immunohistochemical Evidence for Impaired NO Signaling in the Hypothalamus of Depressed Patients
H.-G. BERNSTEINa,
A. HEINEMANNa,
D. KRELLa,
C. MAWRINb,
H. BIELAUa,
P. DANOSa,
S. DIEKMANNa,
G. KEILHOFFc,
B. BOGERTSa AND
B. BAUMANNa
aDepartments of Psychiatry and bNeuropathology, and cInstitute of Medical Neurobiology, University of Magdeburg, D-39120 Magdeburg, Germany
Address for correspondence: H.-G. Bernstein, Department of Psychiatry, University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany. Voice: +49 391 67 14249; fax: +49 391 67 15223.
Hans-Gert.Bernstein{at}medizin.uni-magdeburg.de
Ann. N.Y. Acad. Sci. 973: 91-93 (2002).
The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS-immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling.
Key Words: nitric oxide synthase • neurophysin • immunohistochemistry • suprachiasmatic nucleus • depression
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