 | CELLULAR AND MOLECULAR PHYSIOLOGY OF SODIUM-CALCIUM EXCHANGE: PROCEEDINGS OF THE FOURTH INTERNATIONAL CONFERENCE
Copyright © 2002 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 976:41-52 (2002)
© 2002 New York Academy of Sciences
The Na/Ca-K Exchanger Gene Family
ROBERT T. SZERENCSEI,
ROBERT J. WINKFEIN,
CONAN B. COOPER,
CLEMENS PRINSEN,
TASHI G. KINJO,
KYEONGJIN KANG AND
PAUL P.M. SCHNETKAMP
Department of Biophysics & Physiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Address for correspondence: Paul P.M. Schnetkamp, Department of Physiology & Biophysics, Faculty of Medicine, Health Sciences Centre, University of Calgary, 3330 Hospital Dr. N.W., Calgary, AB T2N 4N1, Canada. Voice: 403-220-6862; fax: 403-283-8731.
pschnetk{at}ucalgary.ca
Ann. N.Y. Acad. Sci. 976: 41-52 (2002).
Ca 2+ extrusion driven by both the inward Na + gradient as well as the outward K + gradient is essential for visual transduction in retinal rod and cone photoreceptors because it removes Ca 2+ that enters photoreceptors via the cGMP-gated and light-sensitive channels. We have cloned rod and cone Na/Ca-K exchanger (NCKX) cDNAs from several species, and we have cloned NCKX cDNAs from lower organisms that lack vertebrate-type vision. Although in situ NCKX physiology has only been documented for vertebrate photoreceptors, it is now clear that NCKX gene products have a much broader distribution pattern. Here, we review some of the structural and functional features that have emerged from our studies on different members of the NCKX gene family.
Key Words: Ca2+ • Na/Ca-K exchanger • NCKX proteins • genes • transmembrane-spanning segments • High Five cells • expression systems
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