 | EPIGENETICS IN CANCER PREVENTION: EARLY DETECTION AND RISK ASSESSMENT
Copyright © 2003 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 983:213-219 (2003)
© 2003 New York Academy of Sciences
Epigenetics in Carcinogenesis and Cancer Prevention
PETER A. JONES
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9181, USA
Address for correspondence: Peter A. Jones, Ph.D., Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90089-9181. Voice: 323-865-0816; fax: 323-865-0102.
jones_p{at}ccnt.hsc.usc.edu
Ann. N.Y. Acad. Sci. 983: 213-219 (2003).
Carcinogenesis is a stepwise process of accumulation of genetic and epigenetic abnormalities that can lead to cellular dysfunction. It has become clear that epigenetic changes are equally important for this multistep process to produce its results. This article describes the different roles that epigenetic modulation may play during carcinogenesis and how an early detection and chemopreventive intervention strategy that takes both sides of the equation into account would be advantageous.
Key Words: epigenetics • carcinogenesis • 5-methylcytosine • CpG island
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