 | EPIGENETICS IN CANCER PREVENTION: EARLY DETECTION AND RISK ASSESSMENT
Copyright © 2003 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 983:243-250 (2003)
© 2003 New York Academy of Sciences
Aberrant DNA Methylation in Ovarian Cancer
Is There an Epigenetic Predisposition to Drug Response?
SUSAN H. WEIa,
ROBERT BROWNb AND
TIM H.-M. HUANGa
aDepartment of Pathology and Anatomical Sciences, Ellis Fischel Cancer Center, University of Missouri School of Medicine, Columbia, Missouri 65203, USA
bCancer Research UK Department of Medical Oncology, University of Glasgow, Beatson Laboratories, Glasgow G61 1BD, United Kingdom
Address for correspondence: Tim H.-M. Huang, Ph.D., Department of Pathology and Anatomical Sciences, Ellis Fischel Cancer Center, University of Missouri, 115 Business Loop I-70 West, Columbia, MO 65203. Voice: 573-882-1276; fax: 573-884-5206.
huangh{at}health.missouri.edu
Ann. N.Y. Acad. Sci. 983: 243-250 (2003).
Epigenetic regulation of gene expression has been observed in a variety of tumor types. We have used microarray technology to evaluate the predisposition of drug response by aberrant methylation in ovarian cancer. Results indicate that loss of gene activity due to hypermethylation potentially confers a predisposition in certain cancer types and is an early event in disease progression. Methylation profiles of ovarian cancer might be useful for early cancer detection and prediction of chemotherapy outcome in a clinical context.
Key Words: DNA methylation • microarray • high-throughput • drug-resistance • chemotherapy • cisplatin • mismatch repair
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