 | EPIGENETICS IN CANCER PREVENTION: EARLY DETECTION AND RISK ASSESSMENT
Copyright © 2003 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 983:43-54 (2003)
© 2003 New York Academy of Sciences
Genetic and Epigenetic Mosaicism in Cancer Precursor Tissues
BENJAMIN TYCKO
Institute for Cancer Genetics and Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Address for correspondence: Benjamin Tycko, Institute for Cancer Genetics and Department of Pathology, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032. Voice: 212-851-5280; fax: 212-851-5284.
bt12{at}columbia.edu
Ann. N.Y. Acad. Sci. 983: 43-54 (2003).
The concept of field effects in cancer is old, but recent molecular data have substantiated it. Clones of cells that carry well-defined genetic or epigenetic aberrations, but which have not yet acquired the morphological hallmarks of neoplasia, have been documented in the precursor tissues of some of the most common pediatric and adult malignancies. Here I review this evidence, focusing on loss of heterozygosity (LOH) and gain of DNA methylation.
Key Words: genetics • epigenetics • mosaicism • genomic imprinting • cancer • loss of heterozygosity • field effects • DNA methylation
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