 | THE AMYGDALA IN BRAIN FUNCTION: Basic and Clinical Approaches
Copyright © 2003 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 985:389-410 (2003)
© 2003 New York Academy of Sciences
Neuroimaging Studies of Amygdala Function in Anxiety Disorders
SCOTT L. RAUCHa,b,
LISA M. SHINa,b,c AND
CHRISTOPHER I. WRIGHTa,d
aDepartment of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
bDepartment of Psychiatry Harvard Medical School, Boston, Massachusetts, USA
cDepartment of Psychology, Tufts University, Medford, Massachusetts, USA
dDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Address for correspondence: Scott L. Rauch, M.D., Director, Psychiatric Neuroimaging Research, Department of Psychiatry, Massachusetts General Hospital—East, Building 149, Room 9130, 13th Street, Charlestown, Massachusetts 02129. Voice: 617-724-9553; fax: 617-726-4078.
rauch{at}psych.mgh.harvard.edu
Ann. N.Y. Acad. Sci. 985: 389-410 (2003).
Neuroimaging research has helped to advance neurobiological models of anxiety disorders. The amygdala is known to play an important role in normal fear conditioning and is implicated in the pathophysiology of anxiety disorders. The amygdala may also be a target for the beneficial effects of cognitive-behavioral and medication treatments for anxiety disorders. In the current paper, we review neuroimaging research pertaining to the role of the amygdala in anxiety disorders and their treatment. Moreover, we discuss the development of new neuroimaging paradigms for measuring aspects of amygdala function, as well as the function of related brain regions. We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains.
Key Words: functional magnetic resonance imaging • positron emission tomography • posttraumatic stress disorder • phobias • obsessive-compulsive disorder • panic disorder
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