 | Na,K-ATPase AND RELATED CATION PUMPS: Structure, Function, and Regulatory Mechanisms
Copyright © 2003 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 986:660-668 (2003)
© 2003 New York Academy of Sciences
Genetics of Hypertension: The Adducin Paradigm
GIUSEPPE BIANCHIa AND
GRAZIA TRIPODIb
aChair and School of Nephrology, Division of Nephrology, Dialysis, and Hypertension, Università Vita e Salute, San Raffaele Hospital, Milan, Italy
bPrassis-Sigma Tau Research Institute, Settimo Milanese, Milan, Italy
Address for correspondence: Giuseppe Bianchi, Divisione di Nefrologia, Dialisi, e Ipertensione, Università Vita e Salute, Ospedale San Raffaele, Via Olgettina, 20132 Milano, Italia. Voice: +39-2-26433006; fax: +39-2-26432384.
bianchi.giuseppe{at}hsr.it
Ann. N.Y. Acad. Sci. 986: 660-668 (2003).
The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na-K pump; and (4) future directions.
Key Words: adducin • genetics • hypertension • Na-K pump • endocytosis • tubular renal reabsorption
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