 | Na,K-ATPase AND RELATED CATION PUMPS: Structure, Function, and Regulatory Mechanisms
Copyright © 2003 by the New York Academy of Sciences
description
Annals of the New York Academy of Sciences 986:678-684 (2003)
© 2003 New York Academy of Sciences
Ouabain as a Mammalian Hormone
WILHELM SCHONERa,
NATALI BAUERb,
JOCHEN MÜLLER-EHMSENc,
ULRIKE KRÄMERd,
NJDE HAMBARCHIANc,
ROBERT SCHWINGERc,
HANS MOELLERd,
HOLGER KOSTa,
CHRISTINE WEITKAMPa,
THOMAS SCHWEITZERa,
ULRIKE KIRCHa,
HORST NEUb AND
ERNST-GÜNTHER GRÜNBAUMb
aInstitute of Biochemistry and Endocrinology, Justus-Liebig-University Giessen, D-35392 Giessen, Germany
bClinic for Small Animal Internal Medicine and Forensic Affairs, Justus-Liebig-University Giessen, D-35392 Giessen, Germany
cThird Clinic of Internal Medicine, University of Cologne, Cologne, Germany
dClinic of Internal Medicine, University of Tübingen, Tübingen, Germany
Address for correspondence: Dr. Wilhelm Schoner, Institut für Biochemie und Endokrinologie, Justus-Liebig-Universität Giessen, Frankfurter Strasse 100, D-35392 Giessen, Germany. Voice: +49-641-99-38170; fax: +49-641-99-38179.
wilhelm.schoner{at}vetmed.uni-giessen.de
Ann. N.Y. Acad. Sci. 986: 678-684 (2003).
Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the µ chain of IgM whose hydrophobic surfaces interact with cardiotonic steroids and cholesterol. Such IgM complexes might be involved in the hepatic elimination of cardiotonic steroids. Thus, differences in the signaling cascade starting at Na +,K +-ATPase must explain any differences in the action of ouabain and digoxin in the genesis of arterial hypertension.
Key Words: control of endogenous ouabain • epinephrine • angiotensin II • arterial hypertension • cardiac glycoside binding protein • IgM • µ chain
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