 | NEUROENDOCRINE AND NEURAL REGULATION OF AUTOIMMUNE AND INFLAMMATORY DISEASE: Molecular, Systems, and Clinical Insights
Copyright © 2003 by the New York Academy of Sciences
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Annals of the New York Academy of Sciences 992:218-230 (2003)
© 2003 New York Academy of Sciences
The Role of Neural Inflammation in Asthma and Chronic Obstructive Pulmonary Disease
GUY F. JOOS,
KATELIJNE O. DE SWERT,
VANESSA SCHELFHOUT AND
ROMAIN A. PAUWELS
Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
Address for correspondence: Prof. Dr. Guy F. Joos, Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. Voice: 32 9 240 2359; fax: 32 9 240 2341.
guy.joos{at}rug.ac.be
Ann. N.Y. Acad. Sci. 992: 218-230 (2003).
The tachykinins substance P and neurokinin A are found within airway nerves and immune cells. They have various effects on the airways that can contribute to the changes observed in asthma and chronic obstructive pulmonary disease. Both tachykinin NK 1 and NK 2 receptors have been involved in the bronchoconstriction and the proinflammatory changes induced by substance P and neurokinin A. Tachykinin NK 1 and NK 2 receptor antagonists have activity in various animal models of allergic asthma and chronic bronchitis. It is suggested that dual NK 1/NK 2 and triple NK 1/NK 2/NK 3 tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases.
Key Words: substance P • neurokinin A • tachykinins • asthma • neurogenic airway inflammation • tachykinin receptor antagonists
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