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Ann. N.Y. Acad. Sci., Annals PrePrint, published online ahead of print September 28, 2007 doi: 10.1196/annals.1393.013 Copyright © 2007 by the New York Academy of Sciences description
1 Director's Office, Feinstein Institute for Medical Research, Manhasset, New York, United States 2 Director and CEO, Feinstien Institute for Medical Research, Manhasset, New York, United States
* To whom correspondence should be addressed. E-mail: rollingthunder{at}optonline.net. PrePrint Abstract
The body's first defense against invading pathogens or tissue injury is the innate immune system. Since excessive immune responses can be damaging, anti-inflammatory mechanisms function to control the pro-inflammatory response and prevent injury. The cholinergic anti-inflammatory pathway is a neural mechanism that suppresses the innate inflammatory response. Knowledge concerning innervation of the immune system offers a unique opportunity to explore previously unrecognized or under recognized techniques to treat disease. It also enables consideration of the neurological basis of complementary and alternative medical therapies, such as meditation and acupuncture. This evolving area of research has implications for the pathogenesis of chronic inflammatory conditions including inflammatory bowel disease, rheumatoid arthritis, type 2 diabetes, and other conditions of excessive cytokine release. Key Words:
cytokine, TNF , Inflammation, cholinergic anti-inflammatory pathway, inflammatory reflex, complementary and alternative medical therapies
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