Tibetan medicine integrates diet, lifestyle, herbs and accessory therapies to increase health and longevity. A comparison of the three humor theory of Tibetan medicine and the three thermodynamic phase properties of myelin lipids exemplifies how integrating medical systems can increase understanding of complex chronic disabling conditions. The physical disruption of central nervous system myelin membranes in multiple sclerosis (MS) is interpreted from the perspective of the three humors (vital energies) of Tibetan medicine: rLung (Wind), MKhris pa (Bile) and Bad gen (Phlegm). The three classes of myelin lipids - phospholipids, sphingolipids, and cholesterol - are interpreted as one of the three humors based on Langmuir isotherm thermodynamic measurements. The nature of rLung is movement or change. Myelin sphingolipids are interpreted as rLung based on thermodynamic properties of changes in phase organization. MKhris pa is fire, energetic. Phospholipids are interpreted as MKhris pa based on thermodynamic properties of being energetic membrane lipids with fast molecular motions and fluid-like properties. The nature of Bad gen is substance and form; it dominates body structure. Cholesterol relates to Bad gen because it dominates membrane structure. Myelin lipid data is presented to support this interpretation. Demyelination in MS is a continuum of imbalances of the three humors. In general, MS is a Wind-Bile disorder in women and a Phlegm-Bile disorder in men, with Wind-Bile excess in both genders during exacerbation, inflammation and demyelination. Studying Tibetan medicine in its traditional context will create an integrative model for the treatment of MS and other chronic conditions.