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Ann. N.Y. Acad. Sci., Annals PrePrint, published online ahead of print March 1, 2007
doi: 10.1196/annals.1384.008
Copyright © 2007 by the New York Academy of Sciences
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Articles by Granger, D. A.
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Articles by Granger, D. A.
Articles by Stroud, L.
Salivary Alpha-amylase in Biobehavioral Research: Recent Developments and Applications

Douglas Alan Granger 1*, Katie T Kivlighan 2, Mona El-Sheikh 3, Elana Gordis 4, Laura Stroud 5

1 Biobehavioral Health, Pennsylvania State University, 315 East Henderson, University Park, 16802, United States
2 University Park, United States
3 Auburn, United States
4 Albany, United States
5 Providence, United States

* To whom correspondence should be addressed. E-mail: dag11{at}psu.edu.

PrePrint Abstract

In the history of science, technical advances often precede periods of rapid accumulation of knowledge. Within the past three decades, discoveries that enabled the non-invasive measurement of the psychobiology of stress (in saliva) have added new dimensions to the study of health and human development. The widespread enthusiasm has lead to somewhat of a renaissance in behavioral science. At the cutting edge, the focus is on testing innovative theoretical models of individual differences in behavior as a function of multi-level biosocial processes in the context of everyday life. Several new studies have generated renewed interest in salivary {alpha}-amylase (sAA) as a surrogate marker of the autonomic/sympathetic nervous system component of the psychobiology of stress. This paper reviews sAA's properties and functions; presents illustrative findings relating sAA to stress and the physiology of stress, behavior, cognitive function and health; and provides practical information regarding specimen collection and assay. The overarching intent is to accelerate the learning curve such that investigators avoid potential pitfalls associated with integrating this unique salivary analyte into the next generation of biobehavioral research.

Key Words: saliva, alpha-amylase, Biobehavioral Research




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