Molecular Mechanisms and Models of Aging Volume 1119 published December 2007 Index of Authors description | purchase this volume

Contents Frontmatter Part I. Overview of Mammalian Aging and Senescence Part II. Cell Signaling and Replicative Senescence Part III. Biomarkers of Aging Part IV. DNA Repair and Aging Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance Part VI. Intervention Part VII. Molecular Links between Aging and Cancer Part VIII. Age-Related Diseases Part IX. Model Organisms Part X. Evolutionary and Epidemiological Aspects of Aging

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EFSTATHIOS S. GONOS, IOANNIS P. TROUGAKOS, and NIKI CHONDROGIANNI
Preface
Ann NY Acad Sci 1119: xi–xii. [Full Text] [PDF]  

Part I. Overview of Mammalian Aging and Senescence:

GEORGE M. MARTIN
Clonal Attenuation of Somatic Cells in Aging Mammals: A Review of Supportive Evidence and Its Biomedical Significance
Ann NY Acad Sci 1119: 1–8. [Abstract] [Full Text] [PDF]  

Part II. Cell Signaling and Replicative Senescence:

EFTHYMIOS POULIOS, IOANNIS P. TROUGAKOS, NIKI CHONDROGIANNI, and EFSTATHIOS S. GONOS
Exposure of Human Diploid Fibroblasts to Hypoxia Extends Proliferative Life Span
Ann NY Acad Sci 1119: 9–19. [Abstract] [Full Text] [PDF]  

DOMINICK G. A. BURTON, ANGELA N. SHEERIN, ELIZABETH L. OSTLER, KAYE SMITH, PETER J. GILES, JILL LOWE, WILLIAM RHYS-WILLIAMS, DAVID G. KIPLING, and RICHARD G. A. FARAGHER
Cyclin D1 Overexpression Permits the Reproducible Detection of Senescent Human Vascular Smooth Muscle Cells
Ann NY Acad Sci 1119: 20–31. [Abstract] [Full Text] [PDF]  

Part III. Biomarkers of Aging:

EARL GOYARTS, NEELAM MUIZZUDDIN, DANIEL MAES, and PAOLO U. GIACOMONI
Morphological Changes Associated with Aging: Age Spots and the Microinflammatory Model of Skin Aging
Ann NY Acad Sci 1119: 32–39. [Abstract] [Full Text] [PDF]  

E. MAKRANTONAKI and C. C. ZOUBOULIS
Molecular Mechanisms of Skin Aging: State of the Art
Ann NY Acad Sci 1119: 40–50. [Abstract] [Full Text] [PDF]  

Part IV. DNA Repair and Aging:

SÉBASTIEN MARTIEN and CORINNE ABBADIE
Acquisition of Oxidative DNA Damage during Senescence: The First Step toward Carcinogenesis?
Ann NY Acad Sci 1119: 51–63. [Abstract] [Full Text] [PDF]  

T. G. SOURLINGAS, K. P. KYPREOU, G. N. TOPAKAS, I. N. KARCHILAKI, C. STAVROPOULOS-GIOKAS, and K. E. SEKERI-PATARYAS
Effect of the Histone Deacetylase Inhibitor Trichostatin A in Human Peripheral Blood Lymphocytes as a Function of Donor Age
Ann NY Acad Sci 1119: 64–71. [Abstract] [Full Text] [PDF]  

Part V. Free Radicals, Oxidative Stress, Proteolysis and Proteins Maintenance:

CELINE BORLON, ALINE CHRETIEN, FLORENCE DEBACQ-CHAINIAUX, and OLIVIER TOUSSAINT
Transient Increased Extracellular Release of H₂O₂ during Establishment of UVB-Induced Premature Senescence
Ann NY Acad Sci 1119: 72–77. [Abstract] [Full Text] [PDF]  

JENNY K. NGO and KELVIN J. A. DAVIES
Importance of the Lon Protease in Mitochondrial Maintenance and the Significance of Declining Lon in Aging
Ann NY Acad Sci 1119: 78–87. [Abstract] [Full Text] [PDF]  

EMAD KHAIRY AHMED, CÉDRIC R. PICOT, ANNE-LAURE BULTEAU, and BERTRAND FRIGUET
Protein Oxidative Modifications and Replicative Senescence of WI-38 Human Embryonic Fibroblasts
Ann NY Acad Sci 1119: 88–96. [Abstract] [Full Text] [PDF]  

TOBIAS JUNG, NICOLLE BADER, and TILMAN GRUNE
Lipofuscin: Formation, Distribution, and Metabolic Consequences
Ann NY Acad Sci 1119: 97–111. [Abstract] [Full Text] [PDF]  

Part VI. Intervention:

SURESH I. S. RATTAN, HENRIK SEJERSEN, RICARDO A. FERNANDES, and WEIWEI LUO
Stress-Mediated Hormetic Modulation of Aging, Wound Healing, and Angiogenesis in Human Cells
Ann NY Acad Sci 1119: 112–121. [Abstract] [Full Text] [PDF]  

ÜLO KRISTJUHAN
Real Aging Retardation in Humans through Diminishing Risks to Health
Ann NY Acad Sci 1119: 122–128. [Abstract] [Full Text] [PDF]  

EUGENIO MOCCHEGIANI, ROBERTINA GIACCONI, CATIA CIPRIANO, LAURA COSTARELLI, ELISA MUTI, SILVIA TESEI, CINZIA GIULI, ROBERTA PAPA, FIORELLA MARCELLINI, ERMINIA MARIANI, LOTHAR RINK, GEORGE HERBEIN, AUDREY VARIN, TAMAS FULOP, DANIELA MONTI, JOLANTA JAJTE, GEORGE DEDOUSSIS, EFSTATHIOS S. GONOS, IOANNIS P. TROUGAKOS, and MARCO MALAVOLTA
Zinc, Metallothioneins, and Longevity:: Effect of Zinc Supplementation: Zincage Study
Ann NY Acad Sci 1119: 129–146. [Abstract] [Full Text] [PDF]  

ROY G. SMITH, YUXIANG SUN, HONG JIANG, ROSIE ALBARRAN-ZECKLER, and NIKOLAI TIMCHENKO
Ghrelin Receptor (GHS-R1A) Agonists Show Potential as Interventive Agents during Aging
Ann NY Acad Sci 1119: 147–164. [Abstract] [Full Text] [PDF]  

Part VII. Molecular Links between Aging and Cancer:

CUSTER C. DEOCARIS, NASHI WIDODO, TETSURO ISHII, SUNIL C. KAUL, and RENU WADHWA
Functional Significance of Minor Structural and Expression Changes in Stress Chaperone Mortalin
Ann NY Acad Sci 1119: 165–175. [Abstract] [Full Text] [PDF]  

SABINE FIMMEL, LENA DEVERMANN, ANKE HERRMANN, and CHRISTOS ZOUBOULIS
GRO-: A Potential Marker for Cancer and Aging Silenced by RNA Interference
Ann NY Acad Sci 1119: 176–189. [Abstract] [Full Text] [PDF]  

HENRIQUE ALMEIDA, LILIANA MATOS, and DELMINDA NEVES
Caspase-3 and Bcl-2 Expression in Aging in Adrenal Zona Reticularis After Dexamethasone Administration
Ann NY Acad Sci 1119: 190–195. [Abstract] [Full Text] [PDF]  

Part VIII. Age-Related Diseases:

F. MAROTTA, K. KOIKE, A. LORENZETTI, Y. NAITO, F. FAYET, H. SHIMIZU, and P. MARANDOLA
Nutraceutical Strategy in Aging: Targeting Heat Shock Protein and Inflammatory Profile through Understanding Interleukin-6 Polymorphism
Ann NY Acad Sci 1119: 196–202. [Abstract] [Full Text] [PDF]  

CARMELA RITA BALISTRERI, GIUSEPPINA CANDORE, FLORINDA LISTÌ, TERESA FAZIO, SIMONA GANGI, EGLE INCALCATERRA, MARCO CARUSO, MAURIZIO LI VECCHI, DOMENICO LIO, and CALOGERO CARUSO
Role of TLR4 Polymorphisms in Inflammatory Responses: Implications for Unsuccessful Aging
Ann NY Acad Sci 1119: 203–207. [Abstract] [Full Text] [PDF]  

RAYA AL-SHAWI, ANGELA HAFNER, SOYON CHUN, SABA RAZA, KEITH CRUTCHER, CHRISTOPHER THRASIVOULOU, PAUL SIMONS, and TIMOTHY COWEN
ProNGF, Sortilin, and Age-related Neurodegeneration
Ann NY Acad Sci 1119: 208–215. [Abstract] [Full Text] [PDF]  

TAKUYA CHIBA, SATOSHI FUJITA, HARUAKI KUBOTA, DAISUKE INOUE, AYA MIZUNO, TOSHIMITSU KOMATSU, HARUYOSHI YAMAZA, YOSHIKAZU HIGAMI, and ISAO SHIMOKAWA
Identification of Fasting-induced Genes in the Rat Hypothalamus: Relationship with Neuroprotection
Ann NY Acad Sci 1119: 216–226. [Abstract] [Full Text] [PDF]  

FEDERICO LICASTRO, MARTINA CHIAPELLI, CLAUDIO MARCELLO CALDARERA, CALOGERO CARUSO, DOMENICO LIO, and ELIZABETH H. CORDER
Acute Myocardial Infarction and Proinflammatory Gene Variants
Ann NY Acad Sci 1119: 227–242. [Abstract] [Full Text] [PDF]  

V. V. POVOROZNYUK, N. I. DZEROVICH, and T. A. KARASEVSKAYA
Bone Mineral Density in Ukrainian Women of Different Age
Ann NY Acad Sci 1119: 243–252. [Abstract] [Full Text] [PDF]  

Part IX. Model Organisms:

DIANA MCCULLOCH and DAVID GEMS
Sex-specific Effects of the DAF-12 Steroid Receptor on Aging in Caenorhabditis elegans
Ann NY Acad Sci 1119: 253–259. [Abstract] [Full Text] [PDF]  

JAMES M. LUCHAK, LEENA PRABHUDESAI, RAJINDAR S. SOHAL, SVETLANA N. RADYUK, and WILLIAM C. ORR
Modulating Longevity in Drosophila by Over- and Underexpression of Glutamate-Cysteine Ligase
Ann NY Acad Sci 1119: 260–273. [Abstract] [Full Text] [PDF]  

LYNNE S. COX, DAVID J. CLANCY, IVAN BOUBRIAK, and ROBERT D. C. SAUNDERS
Modeling Werner Syndrome in Drosophila melanogaster: Hyper-recombination in Flies Lacking WRN-like Exonuclease
Ann NY Acad Sci 1119: 274–288. [Abstract] [Full Text] [PDF]  

POPI SYNTICHAKI, KOSTOULA TROULINAKI, and NEKTARIOS TAVERNARAKIS
Protein Synthesis Is a Novel Determinant of Aging in Caenorhabditis elegans
Ann NY Acad Sci 1119: 289–295. [Abstract] [Full Text] [PDF]  

Part X. Evolutionary and Epidemiological Aspects of Aging:

AUBREY D. N. J. DE GREY
Calorie Restriction, Post-reproductive Life Span, and Programmed Aging: A Plea for Rigor
Ann NY Acad Sci 1119: 296–305. [Abstract] [Full Text] [PDF]  

ALEXANDER V. KHALYAVKIN and ANATOLI I. YASHIN
Nonpathological Senescence Arises from Unsuitable External Influences
Ann NY Acad Sci 1119: 306–309. [Abstract] [Full Text] [PDF]  

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