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THE METABOLIC SYNDROME X: Convergence of Insulin Resistance, Glucose Intolerance, Hypertension, Obesity, and Dyslipidemias-Searching for the Underlying Defects

Volume 892 published November 1999

Editors:

Barbara Caleen Hansen
JoAnne Saye
Lawrence P. Wennogle

Index of Authors

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Contents

	Introduction
	Part I. Overview of the Physiology of the Metabolic Syndrome
	Part II. Hypertension and Predisposition to the Metabolic Syndrome
	Part III. Adipose Cell Biochemistry and Syndrome X
	Part IV. Regulation of Insulin Receptor Action and Syndrome X
	Part V. Potential Animal Models of Syndrome X: Role of the Central Nervous System
	Part V. Potential Animal Models of Syndrome X: Role of the Central Nervous System: Poster Papers

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Barbara Caleen Hansen, JoAnne Saye, and Lawrence P. Wennogle: Preface; Ann NY Acad Sci 1999 892: ix. [Full Text] [PDF]

Introduction:

BARBARA CALEEN HANSEN: The Metabolic Syndrome X; Ann NY Acad Sci 1999 892: 1-24. [Full Text] [PDF]

Part I. Overview of the Physiology of the Metabolic Syndrome:

P. ZIMMET, E. J. BOYKO, G. R. COLLIER, and M. de COURTEN: Etiology of the Metabolic Syndrome: Potential Role of Insulin Resistance, Leptin Resistance, and Other Players; Ann NY Acad Sci 1999 892: 25-44. [Abstract] [Full Text] [PDF]

GERALD M. REAVEN: Insulin Resistance: A Chicken That Has Come to Roost; Ann NY Acad Sci 1999 892: 45-57. [Abstract] [Full Text] [PDF]

NIR BARZILAI and GAURAV GUPTA: Interaction between Aging and Syndrome X: New Insights on the Pathophysiology of Fat Distribution; Ann NY Acad Sci 1999 892: 58-72. [Abstract] [Full Text] [PDF]

DANIEL PORTE, JR.: Mechanisms for Hyperglycemia in the Metabolic Syndrome: The Key Role of ß-Cell Dysfunction; Ann NY Acad Sci 1999 892: 73-83. [Abstract] [Full Text] [PDF]

Part II. Hypertension and Predisposition to the Metabolic Syndrome:

LEWIS LANDSBERG: Role of the Sympathetic Adrenal System in the Pathogenesis of the Insulin Resistance Syndrome; Ann NY Acad Sci 1999 892: 84-90. [Abstract] [Full Text] [PDF]

JOHN E. HALL, MICHAEL W. BRANDS, and JEFFREY R. HENEGAR: Mechanisms of Hypertension and Kidney Disease in Obesity; Ann NY Acad Sci 1999 892: 91-107. [Abstract] [Full Text] [PDF]

ALAN DAUGHERTY and LISA CASSIS: Chronic Angiotensin II Infusion Promotes Atherogenesis in Low Density Lipoprotein Receptor -/- Mice; Ann NY Acad Sci 1999 892: 108-118. [Abstract] [Full Text] [PDF]

Part III. Adipose Cell Biochemistry and Syndrome X:

ULF SMITH, METTE AXELSEN, EUGENIA CARVALHO, BJÖRN ELIASSON, PER-ANDERS JANSSON, and CHRISTIAN WESSLAU: Insulin Signaling and Action in Fat Cells: Associations with Insulin Resistance and Type 2 Diabetes; Ann NY Acad Sci 1999 892: 119-126. [Abstract] [Full Text] [PDF]

GÉRARD AILHAUD: Cross Talk between Adipocytes and Their Precursors: Relationships with Adipose Tissue Development and Blood Pressure; Ann NY Acad Sci 1999 892: 127-133. [Abstract] [Full Text] [PDF]

JONATHAN K. HAMM, AMR K. EL JACK, PAUL F. PILCH, and STEPHEN R. FARMER: Role of PPAR ${gamma}$ in Regulating Adipocyte Differentiation and Insulin-Responsive Glucose Uptake; Ann NY Acad Sci 1999 892: 134-145. [Abstract] [Full Text] [PDF]

YUJI MATSUZAWA, TOHRU FUNAHASHI, and TADASHI NAKAMURA: Molecular Mechanism of Metabolic Syndrome X: Contribution of Adipocytokines · Adipocyte-derived Bioactive Substances; Ann NY Acad Sci 1999 892: 146-154. [Abstract] [Full Text] [PDF]

CONSTANTINE LONDOS, DAWN L. BRASAEMLE, CHARLES J. SCHULTZ, DIANE C. ADLER-WAILES, DANIEL M. LEVIN, ALAN R. KIMMEL, and CRISTINA M. RONDINONE: On the Control of Lipolysis in Adipocytes; Ann NY Acad Sci 1999 892: 155-168. [Abstract] [Full Text] [PDF]

Part IV. Regulation of Insulin Receptor Action and Syndrome X:

SCOTT A. SUMMERS, VIRAVUTH P. YIN, EILEEN L. WHITEMAN, LUIS A. GARZA, HAN CHO, ROBYN L. TUTTLE, and MORRIS J. BIRNBAUM: Signaling Pathways Mediating Insulin-Stimulated Glucose Transport; Ann NY Acad Sci 1999 892: 169-186. [Abstract] [Full Text] [PDF]

MARY-ELIZABETH PATTI: Nutrient Modulation of Cellular Insulin Action; Ann NY Acad Sci 1999 892: 187-203. [Abstract] [Full Text] [PDF]

IRA D. GOLDFINE, BETTY A. MADDUX, JACK F. YOUNGREN, VINCENZO TRISCHITTA, and LUCIA FRITTITTA: Role of PC-1 in The Etiology of Insulin Resistance; Ann NY Acad Sci 1999 892: 204-222. [Abstract] [Full Text] [PDF]

Part V. Potential Animal Models of Syndrome X: Role of the Central Nervous System:

ELEAZAR SHAFRIR, EHUD ZIV, and LUITGARD MOSTHAF: Nutritionally Induced Insulin Resistance and Receptor Defect Leading to ß-Cell Failure in Animal Models; Ann NY Acad Sci 1999 892: 223-246. [Abstract] [Full Text] [PDF]

HEIDI K. ORTMEYER, NONI L. BODKIN, and BARBARA CALEEN HANSEN: Paradoxical Phosphorylation of Skeletal Muscle Glycogen Synthase by in Vivo Insulin in Very Lean Young Adult Rhesus Monkeys; Ann NY Acad Sci 1999 892: 247-260. [Abstract] [Full Text] [PDF]

FRANÇOISE ROHNER-JEANRENAUD: Neuroendocrine Regulation of Nutrient Partitioning; Ann NY Acad Sci 1999 892: 261-271. [Abstract] [Full Text] [PDF]

PAUL ERNSBERGER, RICHARD J. KOLETSKY, and JACOB E. FRIEDMAN: Molecular Pathology in the Obese Spontaneous Hypertensive Koletsky Rat: A Model of Syndrome X; Ann NY Acad Sci 1999 892: 272-288. [Abstract] [Full Text] [PDF]

MARC L. REITMAN, MARK M. MASON, JAIDEEP MOITRA, OKSANA GAVRILOVA, BERNICE MARCUS-SAMUELS, MICHAEL ECKHAUS, and CHARLES VINSON: Transgenic Mice Lacking White Fat: Models for Understanding Human Lipoatrophic Diabetes; Ann NY Acad Sci 1999 892: 289-296. [Abstract] [Full Text] [PDF]

PER BJÖRNTORP and ROLAND ROSMOND: Hypothalamic Origin of the Metabolic Syndrome X; Ann NY Acad Sci 1999 892: 297-307. [Abstract] [Full Text] [PDF]

Part V. Potential Animal Models of Syndrome X: Role of the Central Nervous System: Poster Papers:

L. BENTHEM, F. KUIPERS, A. B. STEFFENS, and A. J. W. SCHEURINK: Excessive Portal Venous Supply of Long-Chain Free Fatty Acids to the Liver, Leading to Hypothalamus-Pituitary-Adrenal-Axis and Sympathetic Activation as a Key to the Development of Syndrome X: A Proposed Concept for the Induction of Syndrome X; Ann NY Acad Sci 1999 892: 308-311. [Full Text] [PDF]

H.-J. BURGER, G. SCHUBERT, H. HEMMERLE, W. KRAMER, and A. W. HERLING: Pharmacological Interference with Hepatic Glucose Production; Ann NY Acad Sci 1999 892: 312-314. [Full Text] [PDF]

PAUL ERNSBERGER, R. J. KOLETSKY, D. D. KLINE, D. M. BEDOL, and J. E. FRIEDMAN: The SHROB Model of Syndrome X: Effects of Excess Dietary Sucrose; Ann NY Acad Sci 1999 892: 315-318. [Full Text] [PDF]

JENS PIETZSCH, ULRICH JULIUS, CHRISTIAN KIRCH, SABINE FISCHER, and MARKOLF HANEFELD: Very Low Density Lipoprotein Overproduction Is Maximally Expressed in Early Insulin Resistant States; Ann NY Acad Sci 1999 892: 319-322. [Full Text] [PDF]

JENS PIETZSCH, ULRICH JULIUS, and MARKOLF HANEFELD: Metabolic Basis of Low High Density Lipoprotein in Subjects with Impaired Glucose Tolerance; Ann NY Acad Sci 1999 892: 323-326. [Full Text] [PDF]

K. M. PIRKE, H. WURMSER, A. ANGST, R. LAESSLE, and S. E. TRIMBORN: Early Pubertal Development and Overweight in Girls; Ann NY Acad Sci 1999 892: 327-329. [Full Text] [PDF]

ETHAN A. H. SIMS: A Computer Program for Clinical and Investigative Work Related to the Metabolic Syndrome; Ann NY Acad Sci 1999 892: 330-333. [Full Text] [PDF]

MICHAEL F. WIATER and SUE RITTER: Leptin Does Not Attenuate the Hyperphagia Induced by 2-Deoxy-d-Glucose; Ann NY Acad Sci 1999 892: 334-336. [Full Text] [PDF]