Zaven S. Khachaturian and M.-Marsel Mesulam

Preface

Ann NY Acad Sci 2000 924: ix. [Full Text]  

Part I. Theories on Structural Changes: Protein Synthesis, Aggregation, and Degradation: A. Pros and Cons of Amyloid:

P. H. ST GEORGE-HYSLOP

Genetic Factors in the Genesis of Alzheimer's Disease

Ann NY Acad Sci 2000 924: 1-7. [Abstract] [Full Text] [PDF]  

PETER DAVIES

A Very Incomplete Comprehensive Theory of Alzheimer's Disease

Ann NY Acad Sci 2000 924: 8-16. [Abstract] [Full Text] [PDF]  

DENNIS J. SELKOE

Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid ß-Protein

Ann NY Acad Sci 2000 924: 17-25. [Abstract] [Full Text] [PDF]  

BRUCE A. YANKNER

The Pathogenesis of Alzheimer's Disease: Is Amyloid ß-Protein the Beginning or the End?

Ann NY Acad Sci 2000 924: 26-28. [Abstract] [Full Text] [PDF]  

JOHN HARDY

Pathways to Primary Neurodegenerative Disease

Ann NY Acad Sci 2000 924: 29-34. [Abstract] [Full Text] [PDF]  

MARK A. SMITH, JAMES A. JOSEPH, and GEORGE PERRY

Arson: Tracking the Culprit in Alzheimer's Disease

Ann NY Acad Sci 2000 924: 35-38. [Abstract] [Full Text] [PDF]  

KAREN HSIAO ASHE

Synaptic Structure and Function in Transgenic APP Mice

Ann NY Acad Sci 2000 924: 39-41. [Abstract] [Full Text] [PDF]  

Part I. Theories on Structural Changes: Protein Synthesis, Aggregation, and Degradation: B. Cytoskeleton Proteins and Synapses:

M.-MARSEL MESULAM

A Plasticity-Based Theory of the Pathogenesis of Alzheimer's Disease

Ann NY Acad Sci 2000 924: 42-52. [Abstract] [Full Text] [PDF]  

HEIKO BRAAK, KELLY DEL TREDICI, CHRISTIAN SCHULTZ, and EVA BRAAK

Vulnerability of Select Neuronal Types to Alzheimer's Disease

Ann NY Acad Sci 2000 924: 53-61. [Abstract] [Full Text] [PDF]  

JOHN Q. TROJANOWSKI and VIRGINIA M.-Y. LEE

"Fatal Attractions" of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders

Ann NY Acad Sci 2000 924: 62-67. [Abstract] [Full Text] [PDF]  

ELIEZER MASLIAH

The Role of Synaptic Proteins in Alzheimer's Disease

Ann NY Acad Sci 2000 924: 68-75. [Abstract] [Full Text] [PDF]  

KENNETH S. KOSIK

The Long Reach of Evolution and Development: Effects on the Alzheimer Brain

Ann NY Acad Sci 2000 924: 76-80. [Abstract] [Full Text] [PDF]  

Part II. Theories on Functional Changes: A. Risk Factors: ApoE and Estrogen:

JUDES POIRIER

Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism

Ann NY Acad Sci 2000 924: 81-90. [Abstract] [Full Text] [PDF]  

WARREN J. STRITTMATTER

Apolipoprotein E and Alzheimer's Disease

Ann NY Acad Sci 2000 924: 91-92. [Abstract] [Full Text] [PDF]  

PATTIE S. GREEN and JAMES W. SIMPKINS

Estrogens and Estrogen-Like Non-Feminizing Compounds: Their Role in the Prevention and Treatment of Alzheimer's Disease

Ann NY Acad Sci 2000 924: 93-98. [Abstract] [Full Text] [PDF]  

ROBERT M. SAPOLSKY and CALEB E. FINCH

Alzheimer's Disease and Some Speculations about the Evolution of Its Modifiers

Ann NY Acad Sci 2000 924: 99-103. [Abstract] [Full Text] [PDF]  

Part II. Theories on Functional Changes: B. Trophins, Apoptosis, Proteases, and Inflammation:

CASEY LYNCH and WILLIAM MOBLEY

Comprehensive Theory of Alzheimer's Disease: The Effects of Cholesterol on Membrane Receptor Trafficking

Ann NY Acad Sci 2000 924: 104-111. [Abstract] [Full Text] [PDF]  

CARL W. COTMAN and AILEEN J. ANDERSON

The Brain's Microenvironment, Early Functional Loss, and the Conversion to Alzheimer's Disease

Ann NY Acad Sci 2000 924: 112-116. [Abstract] [Full Text] [PDF]  

RALPH A. NIXON

A "Protease Activation Cascade" in the Pathogenesis of Alzheimer's Disease

Ann NY Acad Sci 2000 924: 117-131. [Abstract] [Full Text] [PDF]  

JOSEPH ROGERS and YONG SHEN

A Perspective on Inflammation in Alzheimer's Disease

Ann NY Acad Sci 2000 924: 132-135. [Abstract] [Full Text] [PDF]  

Part III. Theories on Energetics: Circulation, Metabolism, and Oxidation:

J. C. DE LA TORRE

Impaired Cerebromicrovascular Perfusion: Summary of Evidence in Support of Its Causality in Alzheimer's Disease

Ann NY Acad Sci 2000 924: 136-152. [Abstract] [Full Text] [PDF]  

MARK P. MATTSON

Existing Data Suggest That Alzheimer's Disease Is Preventable

Ann NY Acad Sci 2000 924: 153-159. [Abstract] [Full Text] [PDF]  

JOHN M. CARNEY

Oxidative Stress Leading to Loss of Critical Proteases in Alzheimer's Disease: An Alternative View of the Etiology of AD

Ann NY Acad Sci 2000 924: 160-163. [Abstract] [Full Text] [PDF]  

M. FLINT BEAL

Oxidative Metabolism

Ann NY Acad Sci 2000 924: 164-169. [Abstract] [Full Text] [PDF]  

JOHN P. BLASS

The Mitochondrial Spiral: An Adequate Cause of Dementia in the Alzheimer's Syndrome

Ann NY Acad Sci 2000 924: 170-183. [Abstract] [Full Text] [PDF]  

Part IV. Epilogue:

ZAVEN S. KHACHATURIAN

Epilogue: Toward a Comprehensive Theory of Alzheimer's Disease-Challenges, Caveats, and Parameters

Ann NY Acad Sci 2000 924: 184-193. [Abstract] [Full Text] [PDF]  

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